Table 1 Associations of rs9984273 C allele* to disease severity of COVID-19 in meta-analyses
Phenotype of cases and controls (database release) | Number of cases with genotype information | Number of controls with genotype information | Odds Ratio (95% confidence interval) | P value | Number of studies | P value from Cochran's Q heterogeneity test |
|---|---|---|---|---|---|---|
Very severe respiratory confirmed covid vs. not hospitalized covid (release 4) | 269** | 688* | 0.69 (0.46–1.02) | 0.065 | 3 | 0.469 |
Very severe respiratory confirmed covid vs. general population (release 6) | 6321 | 678,513 | 0.93 (0.89–0.98) | 0.006 | 19 | 0.759 |
Hospitalized covid vs. not hospitalized covid (release 6) | 13,582 | 66,291 | 0.96 (0.93–1.00) | 0.035 | 20 | 0.313 |
Hospitalized covid vs. general population (release 6) | 19,876 | 1,450,704 | 0.96 (0.93–0.98) | 0.001 | 33 | 0.291 |
Covid vs. general population (release 6) | 95,644 | 1,752,242 | 0.99 (0.98–1.00) | 0.048 | 60 | 0.318 |