Fig. 2

Rs9984273 is associated with the expression of IFNAR and regulation of MX1 response. A Illustrative examples of IFNAR expression in lung specimens from patients with a CT (left panel) and a TT (right panel) genotype. Arrows indicate the alveolar epithelium and arrowheads the vessels. Stained negative controls are shown in the insets. B Combined expression intensity scores of rs9984273 (CC/CT and TT) and rs2236757 (AG, AA and GG) in lung specimens (n = 9 and 5, respectively). The single CC sample was pooled with CT samples for statistics between CC/CT and TT expressors. Color codes for rs2236757: AG blue, GG black, AA empty. Statistics: Mann–Whitney U-test, two-tailed. C MX1 response. Peripheral blood mononuclear cells (PBMC) were isolated from healthy donors having CC/CT (n = 8) or TT (n = 5) and interferon response was measured with (dark blue) or without (light blue) hydrocortisone (HC) by MX1 upregulation. The graphs show fold change (RQ) compared to the untreated sample (placebo without HC). Significance was calculated using unpaired t test with Welch’s correction