Neurological and respiratory effects of lung protective ventilation in acute brain injury patients without lung injury: brain vent, a single centre randomized interventional study

Table 3 Effect of LPV on neurological outcome variables

Variables	Low VT/low PEEP			Low VT/high PEEP			p^
Variables	Baseline	Intervention	p*	Baseline	Intervention	p*	p^
ICP (mmHg)	10 ± 6	13 ± 7	< 0.001	11 ± 6	13 ± 8	< 0.001	ns
PRx	0.07 ± 0.3	0.04 ± 0.25	ns	0.08 ± 0.25	0.11 ± 0.28	ns	ns
RAP	0.65 ± 0.51	0.78 ± 0.54	< 0.05	0.62 ± 0.44	0.68 ± 0.46	ns	ns
rSO₂ left (%)	68 ± 11	67 ± 12	ns	67 ± 11	65 ± 12	ns	< 0.05
rSO₂ right (%)	68 ± 10	67 ± 10	ns	68 ± 8	65 ± 9	ns	ns

Values are presented as mean ± SD
The results are presented for all patients, independent of whether the intervention was completed or interrupted
p*, p values of paired tests comparing the intervention with the preceding baseline
p^{^}, p values of paired tests comparing the two interventions
27 patients were included in the analysis. N for each variable is stated in Additional file 1: Table S1
ICP intracranial pressure; PRx pressure reactivity index; RAP compensatory reserve index; rSO₂ regional cerebral oxygen saturation

ISSN: 1364-8535