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Table 1 Berlin definition of acute respiratory distress syndrome (ARDS) [2]

From: A structured diagnostic algorithm for patients with ARDS

Timing

Within 1Ā week of risk factora or new/increase in respiratory symptoms

Imaging

Bilateral abnormalities not explained by pleural effusion, collapse or ā€˜nodulesā€™

Origin of pulmonary edema

Insufficiently explained by cardiac failure or overload (if there is not a risk factor for ARDS, an echocardiogram should be performed)

Oxygenation

Ā Mild

200ā€‰<ā€‰PaO2/FiO2ā€‰<ā€‰300Ā mmHg (26ā€‰<ā€‰PaO2/FiO2ā€‰<ā€‰40Ā kPa)ā€‰+ā€‰PEEPā€‰ā‰„ā€‰5Ā cm H2O

Ā Moderate

100ā€‰<ā€‰PaO2/FiO2ā€‰<ā€‰200Ā mmHg (13ā€‰<ā€‰PaO2/FiO2ā€‰<ā€‰26Ā kPa)ā€‰+ā€‰PEEPā€‰ā‰„ā€‰5cmH2O

Ā Severe

PaO2/FiO2ā€‰<ā€‰100Ā mmHg (PaO2/FiO2ā€‰<ā€‰13Ā kPa)ā€‰+ā€‰PEEPā€‰ā‰„ā€‰5Ā cm H2O

  1. PEEP positive end-expiratory pressure
  2. aClinical risk factors: Pneumonia, aspiration, smoke inhalation, near drowning, sepsis, pancreati- tis, trauma, major surgery, blood transfusion (this is referred to as transfusion-related lung injury; TRALI)