Plasma neurofilament light is a predictor of neurological outcome 12 h after cardiac arrest

Table 3 Accuracy of NfL at 95 and 80% sensitivity for prediction of good outcome

	Time point	N	95% sensitivity				80% sensitivity
	Time point	N	Specificity %	Cut-off, pg/mL	NPV%	PPV%	Specificity %	Cut-off, pg/mL	NPV%	PPV%	pAUROC 80–95%
OHCA	0 h	289	20 (7–31)	7	62	73	60 (45–72)	12	56	82	0.66
	12 h	300	71 (59–81)	23	86	87	88 (77–95)	45	67	93	0.88
	48 h	210	74 (64–88)	53	88	89	100 (94–100)	388	69	100	0.95
IHCA	0 h	83	16 (3–26)	9	75	57	37 (11–55)	16	64	61	0.55
	12 h	87	13 (0–47)	9	63	58	55 (29–92)	27	68	70	0.64
	48 h	54	37 (11–68)	30	78	73	79 (42–95)	91	68	88	0.75

Specificities with 95% CI, cut-offs, negative predictive values (NPV), and positive predictive values (PPV) at pre-defined high sensitivities (95% and 80%) for neurofilament light (NfL) on admission (0 h), 12 and 48 h after OHCA and IHCA. The pAUROC presents performance of NfL in the 80–95% sensitivity range. A 95% sensitivity indicates that 5% of the patients with poor outcome had NfL levels below the cut-off. OHCA out-of-hospital cardiac arrest, IHCA in-hospital cardiac arrest, pAUROC partial area under the receiver operating curve

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