Table 2 Biochemical and microbiological data

CSF data

Glucose (mg/dl),median (IQR)

5 (0.4–39)

1.5 (0–10)

0.019

White cell counts (/μL), median (IQR)

2008 (478–6115)

1360 (225–4800)

0.254

Polymorphonuclears (/μL), median (IQR)

1972 (472–5978)

1068 (152–4560)

0.105

Protein (mg/dl), median (IQR)

451 (280–680)

621 (382–1116)

0.003

Culture CSF, n positive/n evaluated (%)

194/218 (88.99)

33/35 (94.29)

0.338

Streptococcus pneumoniae penicillin-non-susceptible,

n/n evaluated (%)

41/154 (26.62)

5/25 (20.00)

0.482

Streptococcus pneumoniae ceftriaxone-non-susceptible,

n/n evaluated (%)

7/106 (0.06%)

0/20 (0%)

0.253

Streptococcus pneumoniae linezolid-non-susceptible,

n/n evaluated (%)

0/44 (0%)

0/10 (0%)

*

Streptococcus pneumoniae vancomycin-non-susceptible,

n/n evaluated (%)

0/86 (0%)

0/12 (0%)

*

Streptococcus pneumoniae-DNA, n positive/n evaluated (%)

28/71 (39.44)

5/13 (38.46)

0.947

Soluble Streptococcus pneumoniae-antigen, n positive/n evaluated (%)

80/116 (68.97)

11/18 (61.11)

0.507

Serum data

White cell counts (× 10³/μL) median (IQR)

17,620 (12,595–23,450)

14,000 (8000–25,600)

0.308

Polymorphonuclears(× 10³/μL), median (IQR)

16,110 (10,900–21,540)

12,724 (7680–24,000)

0.305

Lymphocytes (× 10³/μL), median (IQR)

690 (400–1060)

540 (290–714)

0.048

C-reactive protein (mg/L), median (IQR)

86 (27–227)

161 (28–258)

0.268

Procalcitonin (ng/mL), median (IQR)

6.6 (1.7–16.0)

11.0 (4.6–23)

0.034

Blood culture, n positive/n evaluated (%)

131/193 (67.88)

18/29 (62.07)

0.535