Table 1 Patient, blood gas, and ventilation characteristics
AVDSf < 0.2 (n = 1834) | AVDSf ≥ 0.2–0.3 (n = 274) | AVDSf ≥ 0.3 (n = 227) | p value | |
|---|---|---|---|---|
Patient demographics | ||||
Age (years) | 5.8 (1.3, 13.1) | 6.4 (1.1, 13.9) | 5.2 (0.8, 13.8) | 0.67 |
Male | 1029 (56.1%) | 150 (54.7%) | 139 (61.2%) | 0.28 |
Primary diagnosis | < 0.0001 | |||
Neurologic | 458 (25.0%) | 41 (15.0%) | 28 (12.3%) | |
Respiratory | 515 (28.1%) | 111 (40.5%) | 100 (44.1%) | |
Cardiovascular | 173 (9.4%) | 53 (19.3%) | 51 (22.5%) | |
Gastrointestinal/Renal | 231 (12.6%) | 23 (8.4%) | 10 (4.4%) | |
Hematologic/Oncologic | 64 (3.5%) | 12 (4.4%) | 8 (3.5%) | |
Endocrinologic | 9 (0.5%) | 4 (1.5%) | 4 (1.8%) | |
Trauma | 83 (4.5%) | 12 (4.4%) | 18 (7.9%) | |
Other-Surgical | 240 (13.1%) | 9 (3.3%) | 1 (0.4%) | |
Other-Non Surgical | 61 (3.3%) | 9 (3.3%) | 7 (3.1%) | |
Blood gas and ventilator data for first available AVDSf | ||||
Time from Initiation of Invasive Mechanical Ventilation (d) | 0.11 (0.04, 0.39) | 0.09 (0.04, 0.23) | 0.08 (0.04, 0.20) | 0.0097 |
Time from PICU Admission (d) | 0.15 (0.03, 0.63) | 0.16 (0.05, 0.71) | 0.13 (0.03, 0.20) | 0.36 |
pH | 7.38 (7.33, 7.43) | 7.32 (7.25, 7.38) | 7.24 (7.13, 7.31) | 0.0001 |
PaCO2 | 39 (35, 44) | 46 (38, 55) | 53 (43, 65) | 0.0001 |
FiO2 | 0.40 (0.30, 0.41) | 0.50 (0.40, 0.75) | 0.62 (0.45, 1) | 0.0001 |
VT/kg (ABW) | 7.7 (6.1, 9.4) | 7.0 (5.4, 8.9) | 7.3 (5.3, 9.1) | 0.009 |
MAP | 10 (8, 12) | 13 (10, 18) | 15 (11, 18) | 0.0001 |
PEEP | 5 (5, 7) | 7 (5, 10) | 8 (6, 12) | 0.0001 |
Oxygenation Indexa | 2.7 (1.9, 4.5) | 7.0 (3.5, 15.6) | 9.1 (4.6, 20.4) | 0.0001 |
Severity of illness and outcomes | ||||
PRISM III Score | 4 (2, 8) | 9 (4, 15) | 12 (5, 22) | 0.0001 |
PICU Length of stay in survivors (d) | 5.2 (2.7, 10.5) | 8.2 (3.8, 14.8) | 9.6 (4.7, 18.1) | 0.0001 |
Length of ventilation in survivors (d) | 2.8 (0.9, 6.1) | 4.9 (2.3, 10.4) | 6.1 (2.7, 10.8) | 0.0001 |
PICU mortality | 150 (8.2%) | 67 (24.5%) | 88 (38.8%) | < 0.0001 |