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Table 3 Subgroup analysis and heterogeneity source

From: Does tidal volume challenge improve the feasibility of pulse pressure variation in patients mechanically ventilated at low tidal volumes? A systematic review and meta-analysis

Subgroups

Samples

AUROC (95% CI)

Sensitivity (95% CI)

Specificity (95% CI)

DOR (95% CI)

I2 (%) (95% CI)

Q

P value

Spearman correlation coefficient

Statistical heterogeneity

Heterogeneity source

Patients in ICU group

7

0.95 (0.93, 0.97)

0.91 (0.77, 0.97)

0.88 (0.69, 0.96)

72 (13, 396)

77 (74, 100)

8.53

 < 0.01

0.22

Significant

Others

Supine or semi-recumbent

6

0.95 (0.92, 0.96)

0.88 (0.73, 0.95)

0.89 (0.79, 0.95)

62 (13, 297)

0 (0, 100)

0.42

0.41

1

Very low

Totally threshold effect

Low lung compliance < 30 cm H2O

4

0.96 (0.94, 0.97)

0.89 (0.72, 0.96)

0.91 (0.81, 0.96)

87 (15, 506)

0 (0, 100)

0.51

0.39

1

Very low

Totally threshold effect

PEEP ≥ 5 cm H2O and ≤ 15 cm H2O group

9

0.95 (0.93—0.97)

0.92 (0.82, 0.97)

0.86 (0.73, 0.94)

72 (19, 270)

77 (51, 100)

8.87

 < 0.01

0.19

Significant

Others

Measure tools except TPTD

5

0.94 (0.92, 0.96)

0.91 (0.78, 0.97)

0.87 (0.78, 0.93)

70 (16, 308)

0 (0, 100)

0.86

0.33

1

Very low

Totally threshold effect

Overall data except Yonis 2017

9

0.94 (0.92, 0.96)

0.92 (0.82,0.96)

0.88 (0.82,0 .92)

83 (26, 260)

42 (0, 100)

3.5

0.09

1

Low

Totally threshold effect

Overall date

10

0.96 (0.94, 0.97)

0.92 (0.83, 0.96)

0.88 (0.76, 0.94)

81 (23, 284)

76 (47, 100)

8.3,

 < 0.01

0.06

Significant

Others

  1. TPTD transpulmonary thermodilution, PEEP positive end-expiratory pressure, AUROC area under the receiver operator characteristics curve, DOR diagnostic: odds ratio, CI confidence interval, Q Cochran’s Q test, I2 inconsistencey