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Fig. 3 | Critical Care

Fig. 3

From: Inhaled amikacin for pneumonia treatment and dissemination prevention: an experimental model of severe monolateral Pseudomonas aeruginosa pneumonia

Fig. 3

Antimicrobial pharmacokinetics. A, B AMK and MEM concentrations among study groups by assessment time and matrix. Of note, the AMK concentration only exceeded its MIC for P. aeruginosa in tracheal secretions. C ELF drug concentrations in the right medium (infected) and left upper (non-infected) lobes did not differ when analyzing paired concentrations (p = 0.63). D Non-significantly higher AMK tissue concentrations were observed in more preserved zones. Abbreviations: AMK, inhaled amikacin; ELF, epithelial lining fluid; MEM, IV meropenem; MIC, minimum inhibitory concentration

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Critical Care

ISSN: 1364-8535