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Fig. 1 | Critical Care

Fig. 1

From: Inhaled amikacin for pneumonia treatment and dissemination prevention: an experimental model of severe monolateral Pseudomonas aeruginosa pneumonia

Fig. 1

Lung tissue P. aeruginosa burden. A–C Graphs depict overall, right, and left lung tissue P. aeruginosa colonization, respectively. The red dashed line represents the diagnostic clinical cut-off value for infection. In each group, the median value is indicated by the center horizontal line, and the 95% confidence intervals are indicated by the lower and upper horizontal lines. Red dots represent new isolates resistant to meropenem. D Histopathological analysis of the 90 tissue samples. E Representative photomicrographs of pulmonary tissue retrieved at autopsy. The lung injury score is reported per study group: the CONTROL and MEM + AMK groups show a pattern of confluent pneumonia with bacteria and inflammatory cells between interlobular septa; by contrast, the MEM group shows A more predominant histopathology pattern of pneumonia with inflammatory cells within the alveolar regions, but not confluent through the interlobular septal region. Hematoxylin & eosin staining. Magnification: Upper section =  × 40; Lower section =  × 100. Abbreviations: CONTROL, control; MEM, IV meropenem group; MEM + AMK, meropenem and inhaled amikacin group

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Critical Care

ISSN: 1364-8535