Table 3 Predictors of 60-day after ICU admission mortality in the HIV cohort from OutcomeRea™

Age (years)

 < 38

126 (25.5%)

29 (21.5%)

Ref.

Ref.

 38 to 54

249 (50.4%)

57 (42.2%)

0.96 [0.61; 1.50]

0.87 [0.54; 1.39]

 > 54

119 (24.1%)

49 (36.3%)

1.68 [1.06; 2.67]

1.47 [0.91; 2.36]

Katz independence scale

6 [6; 6]

6 [6; 6]

0.95 [0.76; 1.19]

Sex (male)

333 (67.4%)

107 (79.3%)

1.70 [1.11; 2.58]

1.33 [0.85; 2.07]

Diabetes

37 (7.5%)

11 (8.1%)

1.09 [0.59; 2.02]

Obesity

29 (5.9%)

5 (3.7%)

0.67 [0.27; 1.63]

Chronic disease (KNAUS)

 Hepatic

32 (6.5%)

15 (11.1%)

1.66 [0.97; 2.85]

2.07 [1.15; 3.73]

 Cardiovascular

35 (7.3%)

10 (7.4%)

1.07 [0.56; 2.03]

 Renal

29 (5.9%)

12 (8.9%)

1.59 [0.87; 2.88]

 Respiratory

36 (7.3%)

7 (5.2%)

0.77 [0.36; 1.66]

Solid neoplasia

17 (3.4%)

6 (4.4%)

1.23 [0.54; 2.80]

History of chemotherapy

52 (10.5%)

39 (28.9%)

3.09 [2.04; 4.68]

2.48 [1.54; 4.00]

Inclusion period

 1(1997–2006)

167 (33.8%)

48 (35.6%)

Ref.

Ref.

 2(2007–2015)

263 (53.2%)

72 (53.3%)

0.93 [0.63; 1.38]

0.81 [0.54; 1.22]

 3(2016–2020)

64 (13%)

15 (11.1%)

1.00 [0.55; 1.82]

0.82 [0.44; 1.53]

Medical reason for ICU admission

467 (94.7%)

123 (91.1%)

0.61 [0.33; 1.12]

Main symptom on admission

 Shock

96 (19.4%)

33 (24.4%)

1.28 [0.79; 2.07]

 Acute respiratory distress

184 (37.2%)

42 (31.2%)

0.93 [0.59; 1.47]

 Coma

82 (16.6%)

27 (20%)

1.31 [0.78; 2.18]

 Other

133 (26.7%)

33 (24.4%)

Ref.

SOFA upon ICU admission > 4

262 (53%)

104 (77%)

2.60 [1.73; 3.88]

2.35 [1.56; 3.56]

Pre-ICU hospitalization stay > 24 h

172 (34.8%)

72 (53%)

1.92 [1.36; 2.70]

1.47 [1.03; 2.11]

AIDS

355 (71.9%)

112 (83%)

1.77 [1.12; 2.80]

1.79 [1.11; 2.89]

HIV status (n = 528)

 De novo

63 (15.1%)

15 (13.6%)

Ref.

 Known, uncontrolled

113 (27%)

26 (23.7%)

1.20 [0.68; 2.12]

 Known, controlled

242 (57.9%)

69 (62.7%)

0.98 [0.52; 1.86]

Duration of HIV progression > 10 years (n = 409)

166 (51.7%)

40 (45.4%)

0.82 [0.54; 1.26]

Last CD4 count > 250/mm3 (n = 282)

109 (22.1%)

35 (25.9%)

1.58 [0.92; 2.70]

 < 50

3 (1.5%)

3 (6.1%)

1.63 [0.80; 3.35]

 50 to 200

60 (30.8%)

20 (40.8%)

1.59 [0.88; 2.85]

 > 200

132 (67.7%)

26 (53.1%)

Ref.

Last HIV viral load > 2 Log (n = 260)

107 (50.7%)

22 (44.9%)

0.78 [0.44; 1.38]

ART at ICU admission (n = 531)

244 (58%)

69 (62.7%)

1.21 [0.82; 1.79]

History of AIDS-classifying condition

 Infection

155 (36.8%)

53 (48.2%)

1.47 [1.00; 2.17]

 Hematologic disease

54 (12.8%)

20 (18.2%)

1.18 [0.69; 2.01]

Diagnosis admission according to HIV/AIDS

 AIDS-classifying condition

145 (34.4%)

53 (48.2%)

  Active opportunistic infections

105 (24.9%)

29 (26.4%)

0.98 [0.65; 1.49]

1.39 [0.81; 2.39]

  Active hemopathy

96 (22.8%)

50 (45.5%)

2.59 [1.68; 3.98]

1.52 [0.94; 2.46]

 HANA

43 (10.2%)

16 (14.5%)

1.90 [1.06; 3.39]

1.49 [0.84; 2.64]

 Not associated with HIV

233 (55.3%)

41 (37.3%)

Ref.

Ref.

ART management in ICU (n = 316)

 Suspension

73 (28.1%)

21 (38.2%)

0.98 [0.58; 1.66]

 Resume

20 (7.7%)

0

–

 Continued

167 (64.5%)

33 (57.9%)

0.51 [0.32; 0.83]

 Introduction

22 (8.6%)

4 (7.3%)

0.70 [0.21; 2.27]

Mechanical ventilation during the ICU stay

179 (36.2%)

108 (80%)

5.98 [3.91; 9.14]

Vasopressor during the ICU stay

113 (22.9%)

70 (51.8%)

3.08 [2.19; 4.34]

RRT during the ICU stay

71 (14.4%)

48 (35.6%)

2.84 [1.98; 4.06]

Use of anticancer chemotherapy during the ICU stay

25 (5.1%)

16 (11.8%)

2.22 [1.27; 3.91]