Electric impedance tomography-guided PEEP titration reduces mechanical power in ARDS: a randomized crossover pilot trial

Table 2 Comparison of changes in ventilator parameters with EIT vs tables, for all participants, n = 12

	Change with EIT*	Change with tables**		95% CI of mean difference	p value
Mechanical Power¹, J/min	− 2.50 ± 3.70	1.87 ± 1.61	− 4.36	(− 6.77, − 1.95)	0.002
4ΔP + RR Index, J/min	− 6.80 ± 9.36	4.62 ± 6.25	− 11.42	(− 19.01, − 3.82)	0.007
Elastic–static power², J/min	− 1.37 ± 2.11	0.19 ± 2.28	− 1.56	(− 3.71, 0.58)	0.138
Elastic–dynamic power³, J/min	− 1.13 ± 1.66	0.48 ± 0.88	− 1.61	(− 2.99, − 0.22)	0.027
Resistive power⁴, J/min	0.01 ± 3.30	1.15 ± 2.48	− 1.14	(− 4.59, 2.30)	0.48
Driving Pressure, cmH₂O	− 1.58 ± 2.32	1.34 ± 1.31	− 2.92	(− 4.59, − 1.24)	0.003
PEEP (set), cmH₂O	− 1.17 ± 1.80	0.83 ± 1.80	− 2	(− 3.95, − 0.05)	0.046
Ppeak, cmH₂O	− 2.75 ± 3.55	3.5 ± 2.78	− 6.25	(− 9.79, − 2.71)	0.003
Pplat, cmH₂O	− 2.48 ± 3.22	2.06 ± 1.88	− 4.53	(− 7.45, − 1.62)	0.006
RR, breaths/min	− 0.5 ± 2.35	− 0.75 ± 2.73	0.25	(− 2.71, 3.21)	0.856
Cstat, ml/cmH₂O	3.24 ± 9.85	− 4.6 ± 5.26	7.93	(2.54, 13.32)	0.008
PaO2/FiO2 ratio	25.14 ± 27.11	− 0.89 ± 60.05	26.03	(− 16.01, 68.06)	0.2

Data are listed as mean ± SD
P value calculated using paired t test
*Change with EIT: ventilator parameter at the end of EIT intervention minus ventilator parameter at the start of the EIT intervention
**Change with tables: ventilator parameter at the end of the table intervention minus ventilator parameter at the start of the table intervention
¹Mechanical Power calculate using Gattinoni’s simplified equation
²Elastic–static power, related to PEEP (J/min) = 0.098 * VT * RR * PEEP
³Elastic–dynamic power, related to DP (J/min) = 0.0983 * VT * RR * 0.5 * DP
⁴Resistive power, related to resistance in the ventilator circuit, endotracheal tube, and airways (J/min) = 0.098 * VT * RR *(Ppeak—Pplat)
EIT Electrical Impedance Topography, J joules, min minute, PEEP positive end-expiratory pressure, Ppeak peak pressure, Pplat plateau pressure, RR respiratory rate, Cstat static respiratory system compliance, PaO2 partial pressure of oxygen, FiO2 fraction of inspired oxygen, SD = standard deviation

ISSN: 1364-8535