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Table 3 Mean predicted 28-day probabilities of invasive ventilation and mortality

From: Oxygenation thresholds for invasive ventilation in hypoxemic respiratory failure: a target trial emulation in two cohorts

 

Invasive ventilation (28-day)

Mortality (28-day)

Threshold

MIMIC-IV

AmsterdamUMCdb

MIMIC-IV

AmsterdamUMCdb

Oxygenation thresholds

SF < 110

71.8 (70.4 to 73.0)

50.9 (44.9 to 55.3)

22.2 (19.5 to 25.0)

14.6 (7.7 to 22.3)

SF < 98

47.0 (45.6 to 48.5)

27.7 (19.1 to 34.2)

24.1 (22.0 to 26.9)

13.2 (6.3 to 20.8)

SF < 88

19.4 (18.0 to 20.9)

19.0 (9.2 to 26.2)

25.8 (23.5 to 28.3)

12.7 (6.0 to 20.4)

Usual care

Observed

26.7 (25.2 to 28.2)

36.8 (34.1 to 39.5)

22.2 (20.8 to 23.6)

17.4 (15.3 to 19.6)

Modeled

31.5 (29.7 to 33.5)

45.7 (38.4 to 50.7)

25.1 (22.9 to 27.8)

14.1 (6.7 to 22.3)

Secondary outcomes: respiratory rate

SF < 98 and RR > 25

32.9 (31.4 to 34.4)

24.6 (15.4 to 31.4)

25.0 (22.9 to 27.7)

13.0 (6.3 to 20.7)

SF < 98 and RR > 35

16.3 (15.0 to 17.6)

21.0 (11.3 to 27.9)

25.9 (23.7 to 28.5)

12.8 (6.1 to 20.8)

Secondary outcomes: work of breathing

SF < 98 and abnormal work of breathing

33.5 (31.9 to 35.2)

–

24.9 (22.8 to 27.7)

–

Secondary outcomes: duration

SF < 98 for 2 consecutive hours

27.6 (26.0 to 29.0)

19.9 (10.2 to 26.9)

25.3 (23.2 to 28.1)

12.7 (5.9 to 20.7)

SF < 98 for 4 consecutive hours

19.8 (18.4 to 21.2)

18.1 (8.1 to 25.3)

25.8 (23.6 to 28.3)

12.6 (5.9 to 20.4)

Secondary outcomes: trajectory

SF predicted to be less than 88 in 30 min

67.5 (66.2 to 68.8)

51.0 (44.8 to 55.3)

22.6 (20.1 to 25.4)

14.4 (6.7 to 22.9)

SF predicted to be less than 88 in 60 min

43.0 (41.5 to 44.4)

26.2 (17.1 to 32.9)

24.4 (22.3 to 27.2)

13.0 (6.1 to 21.0)

Secondary outcomes: randomized trial criteria

Respiratory, hemodynamic, or neurologic trial criteria

65.5 (64.2 to 66.8)

64.7 (59.8 to 68.3)

22.5 (19.9 to 25.4)

15.7 (9.0 to 22.3)

Respiratory and hemodynamic or neurologic trial criteria

16.1 (14.8 to 17.5)

19.2 (9.2 to 26.5)

25.9 (23.7 to 28.6)

12.7 (6.1 to 20.4)

  1. This table shows the posterior mean and the 95% credible interval of the mean by threshold for predicted 28-day invasive ventilation and mortality for the primary (MIMIC-IV) and secondary (AmsterdamUMCdb) analyses. Note that all thresholds were evaluated in all patients. SF  Saturation-to-fraction of inspired oxygen ratio, RR  respiratory rate, MIMIC-IV = Medical Information Mart for Intensive Care Version IV, AmsterdamUMCdb = Amsterdam University Medical Center database.
  2. *Predicted SF was calculated using linear extrapolation between the current and previous SF measurements (measurements occurred every 2 h).
  3. **Randomized trial criteria: respiratory criteria = 2 of RR > 40, saturation < 90 on inspired oxygen 0.90 or higher, abnormal work of breathing, or pH < 7.35; hemodynamic criteria = use of breathing, or pH < 7.35; hemodynamic criteria = use of vasopressors; neurologic criteria = Glasgow Coma Scale < 9.
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