The Sequential Organ Failure Assessment (SOFA) Score: has the time come for an update?

Table 2 Some variables that may be considered for inclusion in a Sequential Organ Failure Assessment (SOFA) score version 2.0, while still keeping it simple and accessible to all

Organ system	Current measure	Possible additions/alternatives for consideration
Hepatic	Bilirubin concentration	Clinical assessment of jaundice
Coagulation	Platelet count	Platelet transfusion
Respiratory	PaO₂/FiO₂, respiratory support	SpO₂, HFO, NIV, VV-ECMO
Cardiovascular	Hypotension, norepinephrine, dopamine, dobutamine, agents	Vasopressin (and derivatives), phenylephrine, metaraminol, angiotensin II, other inotropes, VA-ECMO, cardiac support devices, blood lactate
Central nervous system	(Assumed) GCS score	GCS after sedation hold
Renal	Creatinine, urine output	RRT

RRT renal replacement therapy; VA-ECMO venoarterial extracorporeal membrane oxygenation; VV-ECMO venovenous extracorporeal membrane oxygenation; GCS Glasgow Coma Scale; HFO high-flow oxygenation; NIV noninvasive ventilation

ISSN: 1364-8535