Non-interventional follow-up versus fluid bolus in RESPONSE to oliguria in hemodynamically stable critically ill patients: a randomized controlled pilot trial

Table 2 Primary and secondary outcomes

	Follow-up group, n = 63	Fluid bolus group, n = 67	Follow-up group vs Fluid bolus group (95% CI)	P value^c
Primary outcome
Number of patients with doubled urine output (%)	10 (15.9)	22 (32.9)	0.49* (0.23–0.71)	0.026
Secondary outcomes
Change in individual urine output, median [IQR], mL	− 7 [− 19 to 17]	19 [0–53]	− 23** (− 36 to − 10)	0.001
Duration of consecutive oliguria, median [IQR], hours^a	4 [2–8]	2 [0–6]	2** (0–4)	0.038
Cumulative fluid balance 6 h post-randomization, median [IQR], mL^b	678 [518–1029]	1071 [822–1505]	-387** (− 635 to − 213)	< 0.001

Data included from all 130 patients
*Risk ratio
**Median difference
^aUrine output < 0.5 mL/kg/h, data collected to 30d post-randomization or ICU discharge if earlier
^bIncluding fluid input and urine output
^cAdjusted (sepsis and acute kidney injury) median difference or risk ratio with 95% CIs

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