Association between age and the host response in critically ill patients with sepsis

Table 2 Clinical outcome of critically ill sepsis patients stratified by age decade

	< 50 years	≥ 50—< 60 years	≥ 60—< 70 years	≥ 70 years	P value
n	421	368	545	618
ICU-acquired complications, n (%)
Shock	52 (12.4)	43 (11.7)	89 (16.3)	78 (12.6)	0.128
ARDS	13 (3.1)	19 (5.2)	21 (3.9)	22 (3.6)	0.472
Acute kidney injury	25 (5.9)	22 (6.0)	50 (9.2)	42 (6.8)	0.158
ICU-acquired infections	40 (9.5)	33 (9.0)	45 (8.3)	54 (8.7)	0.925
Length of stay, median [IQR]
ICU stay, days^c	3.48 [1.63, 8.49]	4.63 [2.09, 9.35]	3.98 [1.82, 8.50]	3.84 [1.80, 7.79]	0.128
Hospital stay, days^d	18.26 [8.20, 41.80]	22.10 [12.38, 38.38]	19.32 [10.84, 37.75]	18.24 [10.93, 33.17]	0.183
Mortality, n (%)
ICU	54 (12.8)*	70 (19.0)	98 (18.0)	130 (21.0)	0.008
Hospital	80 (19.0)*^ab	106 (28.9)	168 (31.1)	206 (33.3)	< 0.001
Day 30	81 (19.2)*^ab	98 (26.7)*	142 (26.2)*	205 (33.2)	< 0.001
Day 60	99 (23.5)*^a	110 (30.0)*	182 (33.6)	243 (39.3)	< 0.001
Day 90	112 (26.6)*^ab	125 (34.1)*	203 (37.5)	265 (42.9)	< 0.001

Pairwise comparisons were made using the Dunn's Test of Multiple Comparisons Using Rank Sums followed by the Benjamini–Hochberg correction for multiple testing
ARDS acute respiratory distress syndrome, ICU intensive care
*p < 0.05 compared to the ≥ 70 group
^ap < 0.05 compared to the ≥ 60–< 70 years group
^bp < 0.05 compared to the ≥ 50–< 60 years group
^cLength of ICU stay was only calculated in those who survived the entire ICU admission
^dLength of hospital was only calculated in those who survived the entire hospital admission

ISSN: 1364-8535