Fig. 5
From: Association between age and the host response in critically ill patients with sepsis
Gene co-expression networks of nodes with an edge of at least 0.2 of the purple, blue and yellow module, including the top 5 significantly different expressed pathways per pathway database. Gene co-expression networks visualised using Cytoscape 3.0 software. Networks, for which the edge threshold was set to 0.3, are displayed in the left panel. The node colours resemble the log2(Fold change) when comparing patients ≥ 70 to patients < 50 years. Blue colours indicate lower expression in patients ≥ 70, red colours indicate higher expression in patients ≥ 70. The diamond shape resembles a Benjamini–Hochberg (BH)-corrected p-value < 0.05, and ellipses resemble non-significantly different expressed genes. The top 3 hub genes are represented by an increase in size. The right panel portrays the top 5 pathways within the Gene Ontology Biological Process (GO:BP) and top 5 pathways within the Reactome database (REAC) of all genes within the module (independent of the edge). A Purple network and module pathway analysis. B Blue network and module pathway analysis for which the edge threshold of the network was set to 0.33 due to the gene size of the module. C Yellow network and module pathway analysis