Fig. 2
From: Association between age and the host response in critically ill patients with sepsis
Host response biomarkers of critically ill sepsis patients stratified by age decades. Data of 889 patients expressed as box-and-whisker diagrams with whiskers ranging up to 1.5 times the interquartile range in which each panel reflects a host response domain. A Systemic inflammation and cytokine release markers. B Endothelial cell activation and function markers. C Coagulation activation markers. The dotted line represents the median concentration measured in 27 healthy controls. P values were derived form an ANOVA comparing the biomarker concentration between age decades. All p-values are multiple testing corrected using the Benjamini–Hochberg procedure for conducting 17 ANOVA’s (testing 17 biomarkers). Pairwise comparisons using a Dunn’s test were also multiple testing corrected. * p < 0.05, ** p < 0.01, *** p < 0.001. Abbreviations: ANOVA: analysis of variance, adj: adjusted, CRP: C-reactive protein, MMP-8: matrix metalloproteinase-8, TIMP-1: tissue inhibitor of metalloproteinase-1, IL-6: interleukin 6, IL-8: interleukin 8, IL-10: interleukin 10, sE-selectin: soluble E-Selectin, sICAM: soluble Intercellular Adhesion Molecule 1, PT: prothrombin time