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Table 2 Comparison between no/mild chronic kidney disease group and severe chronic kidney disease group at 5 years

From: Predictive factors for severe long-term chronic kidney disease after acute kidney injury requiring renal replacement therapy in critically ill patients: an ancillary study of the ELVIS randomized controlled trial

Variables

No/mild CKD group

Severe CKD group

OR [IC 95%]

p value

Patients, n

96

26

  

Female, n (%)

46 (47.9)

11 (42.3)

0.80 [0.33–1.81]

0.61

Age, years

61 [48.5; 66]

70.5 [62; 76]

1.04 [1.01–1.08]

0.02

BMI at ICU admission, kg/m2

28 [24.2; 34]

26.3 [22; 31.8]

0.97 [0.9–1.05]

0.41

SOFA score at RRT initiation, points

15 [11.5; 17.5]

10.5 [7; 14]

0.85 [0.77; 0.93]

 < .01

SAPS II at ICU admission, points

61 [51.5; 80]

57 [42; 77]

0.99 [0.96–1.01]

0.24

Intermittent modality for the first RRT, n (%)

53 (55.2)

18 (69.2)

1.82 [0.72–4.6]

0.20

Only intermittent modality for RRT, n (%)

43 (44.8)

16 (61.5)

1.97 [0.81–4.79]

0.13

Only continuous modality for RRT, n (%)

23 (24)

4 (15.4)

0.87 [0.22–3.45]

0.84

RRT period, days

20 [8; 35]

29.5 [10; 45]

1.01 [0.99–1.03]

0.35

RRT sessions, n

5 [2; 10]

7.5 [2; 12]

1.02 [0.97–1.07]

0.48

Intermittent RRT sessions, n

4 [2; 8]

5 [2; 11]

1.02 [0.96–1.08]

0.52

Continuous RRT sessions, n

3 [2; 6]

5 [1; 8]

1.04 [0.93–1.16]

0.46

Underlying condition

 No comorbidity, n (%)

23 (24)

10 (38.5)

1.98 [0.79–4.97]

0.14

 Insulin-dependent diabetes, n (%)

11 (11.5)

5 (19.2)

1.84 [0.58–5.87]

0.30

 Chronic hypertension, n (%)

37 (38.5)

10 (38.5)

0.99 [0.41–2.43]

0.99

 Hematological malignancy, n (%)

10 (10.4)

0 (0)

  

 Cirrhosis, n (%)

7 (7.3)

0 (0)

  

 Metastatic cancer, n (%)

1 (1)

0 (0)

  

 Chronic kidney disease*, n (%)

2 (2.1)

2 (7.7)

4.08 [0.78–21.37]

0.10

 Chronic respiratory failure with oxygen therapy, n (%)

2 (1.8)

3 (10.3)

3.92 [0.52–29.25]

0.18

 Chronic heart failure NYHA III or IV, n (%)

12 (12.5)

1 (3.8)

0.28 [0.03–2.26]

0.23

 Immunosuppression**, n (%)

7 (7.3)

4 (15.4)

2.31 [0.62–8.6]

0.21

Main symptom at ICU admission

 Septic shock, n (%)

30 (31.3)

7 (26.9)

0.81 [0.31–2.13]

0.67

 Coma, n (%)

2 (2.1)

1 (3.8)

1.88 [0.16–21.58]

0.61

 Acute respiratory distress, n (%)

17 (17.7)

6 (23.1)

1.39 [0.49–3.99]

0.54

 Acute kidney injury, n (%)

18 (18.8)

5 (19.2)

1.03 [0.34–3.11]

0.96

  1. BMI Body Mass Index, SOFA Sepsis-related Organ Failure Assessment, SAPS Simplified Acute Physiology Score, RRT Renal replacement therapy, NYHA New York Heart Association
  2. *Chronic kidney disease defined as estimated glomerular filtration rate ≤ 60 ml/min/1.73 m2
  3. **Immunosuppression defined as patient with immunosuppressor treatment, chemotherapy, radiotherapy, steroids at least 200 mg/d of hydrocortisone or equivalent for at least 3 months, immunodeficiency induced by diseases such as leukemia, lymphoma, and AIDS