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Table 1 Baseline, ventilation and outcome details of 15 enrolled patients

From: Use of an innovative cuff pressure control and subglottic secretions drainage system in COVID-19 ARDS patients undergoing pronation

Baseline characteristics

 

  Age

65 [56–76]

  Sex (male)

12 (80)

  Cardiovascular Disease

2 (13)

  COPD

0 (0)

  Diabetes

5 (33)

  Liver Disease

2 (13)

  CKD

1 (7)

Ventilation and airway management during AG connection

 AG connection, days

7 [5–10]

 Mean Pcuff value per patient, cmH2O

27.7 [27–29.5]

 SS volume per patient, mL

170 [150–275]

 Mean daily SS volume per patient, mL

31 [21.5–37]

 ETI P/F ratio

84 [79–89]

 Pronation cycles per patient

4 [2–5]

 IMV, days

9 [6–19]

 PEEP, cmH20

9 [8–10]

 Shock during AG

7 (47)

 CRRT during AG

2 (13)

 Patients treated with antibiotics during AG

12 (80)

 Antibiotic therapy during AG, days

5 [3–8]

Outcome measures

 Mean Alpha-amylase level per patient, IU/L*

1774 [1651.5–3066]

 Mean Pepsin level per patient, ng/mL**

15.1 [7.95–22.35]

 Oropharyngeal microaspiration*

47 (55)

 Gastric microaspiration

0 (0)

 Abundant oropharyngeal microaspiration***

9 (60)

 VAP (n)

6 (40)

 Late VAP (n)

6 (100)

 Time between ETI and VAP (days)

8.5 [7.25–9.75]

 Extubation

8 (53)

 Tracheostomy

4 (27)

 Stridor

2 (13)

 ICU LOS (days)

16 [13–24]

 28-day mortality (n)

4 (27)

  1. Categorical variables are expressed in count and percentage; continuous variables are expressed in median and interquartile range
  2. TA tracheal aspirate, CCI Charlson Comorbidity Index, COPD Chronic Obstructive Pulmonary Disease, CKD Chronic Kidney Disease, ETI Endotracheal Intubation, IMV Invasive Mechanical Ventilation, CMV Controlled Mechanical Ventilation, PEEP Positive End-Expiratory Pressure, Pcuff Cuff Pressure, SS subglottic secretions, AG AnapnoGuard, CRRT Continuous Renal Replacement Therapy, VAP Ventilator-Associated Pneumonia, ETI EndoTracheal Intubation, ICU Intensive Care Unit, LOS Length of Stay
  3. *85 samples ** 75 samples
  4. ***Abundant microaspiration of oropharyngeal secretions is defined by the presence of alpha-amylase at a significant concentration (> 1685 IU/mL) in more than 30% of TAs