Table 2 Risk factors for 1-year mortality of the 178,017 adult patients surviving a first episode of sepsis in metropolitan France in 2018: univariate and multivariate logistic regression
cORa (99% CI) | P value | aORa (99% CI) | P value | |
|---|---|---|---|---|
Patient characteristics | ||||
Sex (ref = men) | 0.93 (0.90–0.95) | < 0.001 | 0.97 (0.94–1.01) | 0.034 |
Age (ref = 16–30) | < 0.001 | < 0.001 | ||
31–45 | 2.20 (1.83–2.65) | 1.90 (1.57–2.30) | ||
46–55 | 4.13 (3.47–4.91) | 2.84 (2.38–3.40) | ||
56–65 | 5.76 (4.87–6.81) | 3.49 (2.93–4.14) | ||
66–75 | 7.12 (6.04–8.40) | 4.33 (3.65–5.14) | ||
76–85 | 9.06 (7.68–10.69) | 6.40 (5.39–7.59) | ||
> 85 | 14.01 (11.87–16.54) | 11.33 (9.54–13.47) | ||
Heart failure (ref = no) | 1.38 (1.34–1.43) | < 0.001 | 1.32 (1.27–1.38) | < 0.001 |
Dementia (ref = no) | 2.42 (2.28–2.56) | < 0.001 | 2.02 (1.90–2.15) | < 0.001 |
Chronic pulmonary disease (ref = no) | 1.11 (1.06–1.16) | < 0.001 | 1.18 (1.12–1.24) | < 0.001 |
Rheumathologic diseaseb (ref = no) | 0.99 (0.87–1.13) | 0.908 | ─ | |
Liver disease (ref = no) | 1.15 (1.07–1.22) | < 0.001 | 1.50 (1.40–1.61) | < 0.001 |
Diabetes with chronic complications(ref = no) | 1.07 (1.01–1.14) | 0.003 | 1.06 (0.99–1.14) | 0.024 |
Paraplegia and hemiplegiab (ref = no) | 1.06 (1.00–1.13) | 0.018 | ─ | |
Renal disease (ref = no) | 1.46 (1.40–1.52) | < 0.001 | 1.29 (1.24–1.36) | < .0001 |
Cancer (ref = no) | 3.71 (3.59–3.83) | < 0.001 | 4.35 (4.19–4.52) | < .0001 |
AIDS HIV (ref = no) | 0.58 (0.45–0.76) | < 0.001 | 0.90 (0.68–1.19) | 0.316 |
Hospital stay characteristics | ||||
Hospital readmissionc (ref = no hospital readmission) | < 0.001 | < 0.001 | ||
Recurrent sepsis | 3.48 (3.32–3.64) | 2.93 (2.78–3.09) | ||
Other acute care | 1.41 (1.36–1.47) | 1.25 (1.20–1.30) | ||
ICU admission and septic shock (ref = absence of both) | < 0.001 | < 0.001 | ||
No ICU admission and septic shock | 1.91 (1.72–2.11) | 1.82 (1.63–2.04) | ||
ICU admission and septic shock | 0.68 (0.65–0.71) | 0.83 (0.78–0.87) | ||
ICU admission and no septic shock | 0.62 (0.60–0.64) | 0.73 (0.70–0.76) | ||
Infection characteristics | ||||
Site (ref = Urinary and genital tracts) | < 0.001 | < 0.001 | ||
Gastrointestinal and abdomen | 0.91 (0.85–0.98) | 0.98 (0.90–1.06) | ||
Primary bacteremia | 1.50 (1.43–1.58) | 1.39 (1.31–1.47) | ||
Bones and joints | 0.65 (0.57–0.73) | 0.87 (0.76–0.99) | ||
Heart and mediastinum | 1.48 (1.37–1.60) | 1.39 (1.28–1.51) | ||
Multiple | 1.32 (1.26–1.38) | 1.39 (1.32–1.46) | ||
Material device | 1.26 (1.16–1.37) | 1.20 (1.10–1.32) | ||
Lower respiratory tract | 1.07 (1.02–1.13) | 1.38 (1.30–1.45) | ||
Skin and soft tissues | 1.67 (1.55–1.79) | 1.72 (1.59–1.86) | ||
Others | 0.42 (0.37–0.48) | 0.94 (0.82–1.09) |