Table 3 Heterogeneity of treatment effect to Fluid management strategy within phenotypes in FACTT Trial
From: Longitudinal phenotypes in patients with acute respiratory distress syndrome: a multi-database study
| Â | Class 1 | Class 2 | Class 3 | |||
|---|---|---|---|---|---|---|
Conservative (n = 290) | Liberal (n = 258) | Conservative (n = 156) | Liberal (n = 191) | Conservative (n = 53) | Liberal (n = 45) | |
60-day mortality, n (%) | 47 (16.2) | 50 (19.4) | 48 (30.8) | 74 (39.3) | 31 (58.5) | 16 (35.6) |
| Â | Interaction term | HR (95% CI) | P value for interaction | |||
|---|---|---|---|---|---|---|
Interaction between phenotypes (D0) and Fluid management strategy | ||||||
 60-day mortality, n (%) | Class 1: Class 2 | 0.90 (0.53–1.54) | 0.71 | |||
Class 1: Class 3 | 2.39 (1.16–4.92) | 0.018 | ||||
Class 2: Class 3 | 2.64 (1.30–5.35)) | 0.0068 | ||||