Table 2 Heterogeneity of treatment effect to PEEP strategy within phenotypes in ALVEOLI Trial
From: Longitudinal phenotypes in patients with acute respiratory distress syndrome: a multi-database study
| Â | Class 1 | Class 2 | Class 3 | |||
|---|---|---|---|---|---|---|
Lower PEEP (n = 141) | Higher PEEP (n = 151) | Lower PEEP (n = 55) | Higher PEEP (n = 24) | Lower PEEP (n = 77) | Higher PEEP (n = 97) | |
60-day mortality, n (%) | 23 (16.3) | 33 (21.3) | 13 (23.6) | 13 (54.2) | 32 (41.6) | 30 (30.9) |
| Â | Interaction term | HR (95% CI) | P value for interaction | |||
|---|---|---|---|---|---|---|
Interaction between phenotypes (D0) and PEEP strategy | ||||||
 60-day mortality, n (%) | Class 1: Class 2 | 2.16 (0.85–5.50) | 0.11 | |||
Class 1: Class 3 | 0.49 (0.23–1.02)) | 0.056 | ||||
Class 2: Class 3 | 0.23 (0.09–0.57) | 0.0016 | ||||