Trends in mortality in septic patients according to the different organ failure during 15 years

Lorencio Cárdenas, Carolina; Yébenes, Juan Carlos; Vela, Emili; Clèries, Montserrat; Sirvent, Josep Mª; Fuster-Bertolín, Cristina; Reina, Clara; Rodríguez, Alejandro; Ruiz-Rodríguez, Juan Carlos; Trenado, Josep; Esteban Torné, Elisabeth

doi:10.1186/s13054-022-04176-w

Critical Care

Table 2 Univariate and multivariate analyses of organ failure associated in-hospital mortality by year of admission in Catalonia (2005–2017)

From: Trends in mortality in septic patients according to the different organ failure during 15 years

Univariate analysis				Multivariate analysis
Year	n	Mortality	p	OR	IC95%	p
Respiratory failure
2005	2662	38,8		1	–
2006	2459	37,8		0,8,555,715	0.755–0.970	0.0146
2007	2643	39,2		0,89,399,059	0.791–1.011	0.0731
2008	2799	36,2		0,77,898,524	0.690–0.880	< 0.0001
2009	2996	37,6		0,75,801,748	0.673–0.854	< 0.0001
2010	2816	36,0		0,69,558,657	0.616–0.786	< 0.0001
2011	2802	34,4		0,60,252,572	0.533–0.681	< 0.0001
2012	2776	36,0		0,58,824,668	0.520–0.665	< 0.0001
2013	2891	38,0		0,61,456,548	0.545–0.693	< 0.0001
2014	2642	34,3		0,51,394,317	0.453–0.583	< 0.0001
2015	2745	35,8		0,52,879,873	0.468–0.598	< 0.0001
2016	3380	32,7		0,46,018,306	0.408–0.518	< 0.0001
2017	3849	34,3		0,48,323,359	0.431–0.542	< 0.0001
2018	3742	37,9	< 0.0001	0,56,156,227	0.501–0.630	< 0.0001
2019	3814	35,0		0,4,733,619	0.422–0.531	< 0.0001
					AUC ROC
					0.762 (0.758 – 0.767)
Cardiovascular failure
2005	2491	47,3		1	–
2006	2858	45,7		0,69,393,529	0.615–0.783	< 0.0001
2007	3225	45,7		0,69,297,304	0.616–0.779	< 0.0001
2008	3568	40,8		0,55,888,678	0.498–0.627	< 0.0001
2009	3945	40,5		0,54,844,547	0.490–0.614	< 0.0001
2010	4081	39,4		0,48,303,417	0.431–0.541	< 0.0001
2011	4487	37,1		0,44,050,755	0.394–0.493	< 0.0001
2012	4520	37,1		0,40,863,827	0.365–0.457	< 0.0001
2013	4774	35,5		0,37,430,685	0.335–0.418	< 0.0001
2014	4802	32,8		0,33,977,245	0.304–0.380	< 0.0001
2015	5256	32,7		0,32,401,597	0.290–0.362	< 0.0001
2016	6389	29,6		0,27,741,318	0.249–0.309	< 0.0001
2017	5791	29,9		0,25,132,744	0.225–0.281	< 0.0001
2018	7504	33,0	< 0.0001	0,32,937,548	0.297–0.366	< 0.0001
2019	8238	31,2		0,3,003,618	0.271–0.333	< 0.0001
					AUC ROC
					0.764 (0.761 – 0.768)
CNS failure
2005	1809	16,2		1	–
2006	1676	16,2		1,003,113,881	0.827–1.217	0.9749
2007	2036	15,1		0,984,914,164	0.818–1.186	0.8727
2008	2392	12,9		0,783,057,153	0.651–0.941	0.0092
2009	2648	15,9		0,983,827,452	0.826–1.171	0.8547
2010	2865	13,1		0,821,556,085	0.689–0.980	0.0292
2011	3197	12,4		0,727,698,472	0.611–0.866	0.0003
2012	3860	12,3		0,676,469,996	0.571–0.801	< 0.0001
2013	3855	12,5		0,703,124,481	0.594–0.832	< 0.0001
2014	4237	11,4		0,65,610,759	0.555–0.776	< 0.0001
2015	4704	10,4		0,55,191,349	0.467–0.652	< 0.0001
2016	6238	12,0		0,569,267,239	0.486–0.667	< 0.0001
2017	7081	13,7		0,624,865,732	0.536–0.729	< 0.0001
2018	7542	14,2	< 0.0001	0,673,377,407	0.578–0.784	< 0.0001
2019	7237	14,7		0,64,039,723	0.549–0.746	< 0.0001
					AUC ROC
					0.761 (0.755 – 0.766)
Hematological failure
2005	1089	21,7		1	–
2006	1122	22,4		1,02,282,062	0.808–1.295	0.8513
2007	1218	23,0		1,03,249,027	0.819–1.301	0.7866
2008	1304	20,6		0,85,500,995	0.679–1.077	0.1829
2009	1578	21,2		0,80,145,653	0.643–0.999	0.0492
2010	1705	21,7		0,81,385,536	0.655–1.011	0.0625
2011	1814	20,8		0,7,338,104	0.592–0.910	0.0048
2012	1931	20,2		0,67,176,921	0.542–0.832	0.0003
2013	2141	18,4		0,56,482,716	0.457–0.698	< 0.0001
2014	2060	17,3		0,52,934,679	0.426–0.657	< 0.0001
2015	2239	18,0		0,56,450,526	0.457–0.697	< 0.0001
2016	2822	17,7		0,4,413,267	0.360–0.542	< 0.0001
2017	2883	20,3		0,45,095,202	0.368–0.552	< 0.0001
2018	3327	20,2	< 0.0001	0,529,861	0.435–0.646	< 0.0001
2019	3382	19,2		0,47,667,204	0.391–0.581	< 0.0001
					AUC ROC
					0.835 (0.829 – 0.840)
Liver failure
2005	80	36,2		1	–
2006	96	54,2		1,83,497,874	0.892–3.776	0.0992
2007	119	61,3		1,96,503,495	0.995–3.882	0.0518
2008	107	40,2		0,85,993,432	0.430–1.721	0.6698
2009	147	59,9		2,07,901,315	1.072–4.032	0.0304
2010	149	64,4		1,93,607,915	0.998–3.754	0.0505
2011	186	44,6		0,95,603,365	0.506–1.805	0.8898
2012	240	55,8		1,35,968,041	0.736–2.513	0.3269
2013	252	55,6		1,31,101,581	0.712–2.415	0.3848
2014	250	61,6		1,31,593,221	0.712–2.434	0.3815
2015	371	59,3		1,22,325,659	0.678–2.208	0.5035
2016	365	56,2		0,97,385,455	0.540–1.756	0.9298
2017	382	58,9		0,96,491,164	0.534–1.744	0.9059
2018	514	48,8	< 0.0001	0,72,797,746	0.400–1.326	0.2992
2019	698	49,3		0,68,868,416	0.383–1.239	0.2134
					AUC ROC
					0.801 (0.788 – 0.815)
Kidney failure
2005	4780	25,9		1	–
2006	4937	26,1		0,940,454,002	0.850–1.040	0.2332
2007	5195	26,2		0,923,138,453	0.836–1.020	0.1160
2008	5930	25,3		0,873,826,895	0.793–0.963	0.0065
2009	7090	24,2		0,830,444,748	0.756–0.912	0.0001
2010	8326	22,9		0,758,868,867	0.692–0.832	< 0.0001
2011	10,341	20,5		0,659,592,374	0.603–0.721	< 0.0001
2012	12,025	19,4		0,609,565,863	0.558–0.665	< 0.0001
2013	12,980	18,2		0,53,201,268	0.488–0.580	< 0.0001
2014	13,721	17,9		0,535,202,205	0.491–0.584	< 0.0001
2015	14,896	18,2		0,531,784,828	0.488–0.579	< 0.0001
2016	15,659	17,3		0,456,185,713	0.419–0.497	< 0.0001
2017	17,538	18,1		0,465,317,937	0.428–0.506	< 0.0001
2018	17,311	19,2	< 0.0001	0,511,196,703	0.470–0.556	< 0.0001
2019	17,874	18,5		0,45,881,633	0.422–0.499	< 0.0001
					AUC ROC
					0.783 (0.780 – 0.786)

Data are presented as number of death or %. The multivariate analysis is adjusted by sex, age group, comorbidities, ICU admission, emergency admission, organ dysfunction, number of organ failures, sepsis origin and bacteremia
CI confidence interval, ICU intensive care unit, OR odds ratio, NS non-significant

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