Fig. 4

Effect of Continuous Renal Replacement Therapy on Renal Replacement Therapy Dependence at Day 28 Compared to Intermittent Hemodialysis According to the Different Cohorts Assessed. Panel A, RRT dependence at day 28 considering death as a competing risk. Panel B, RRT dependence at day 28 among survivors at the longest follow-up only. Initial mode considered the mode used after randomization. Mode for the first three days considered patients receiving CRRT or IHD exclusively in the first three days of follow-up (patients who died or do not have information of modality in the first three days were excluded from this analysis). Exclusive mode for the follow-up considered patients receiving CRRT or IHD exclusively during the whole follow-up available for each patient (including those who died early). Adjusted models included for age, gender, weight, type of admission (medical, surgical or other), APACHE III, cardiovascular SOFA, hours between randomization and therapy, use of mechanical ventilation, presence of oliguria, presence of hyperkalemia, presence of sepsis, last bicarbonate, urea and creatinine before randomization, premorbid estimated glomerular filtration rate, and intensity of treatment (as allocated in the original trials)