Table 2 Summary of experimental studies on the effects of inflammation on the central nervous system
From: Acute kidney injury-associated delirium: a review of clinical and pathophysiological mechanisms
Author(s) | Year | Model | Conclusion |
|---|---|---|---|
Rashid et al. | 2021 | UTI in mice Readout: behavioral and structural brain dysfunction | Mice with UTI demonstrated impairments of the frontal cortex and hippocampus, which were reversed following treatment with systemic anti-IL-6 antibody |
An-HsunChou et al. | 2014 | 60Â min bilateral ischemia reperfusion injury-induced AKI Study endpoint/s: 2 and 24Â h Readout: cDNA based microarray | Mice with AKI exhibited upregulated mRNA levels of genes involved in inflammation |
Salama et al. | 2013 | Bilateral renal ischemia reperfusion injury in rats Readout: TLR-4 expression | ↑ TLR-4 expression within hippocampus and striatum |
Liu et al. | 2008 | 60 min bilateral ischemia reperfusion injury-induced AKI Study endpoint: 24 h Readout: Histology | ↑ Neuronal pyknosis and microgliosis ↑ Keratinocyte-derived chemoattractant and G-CSF in the cerebral cortex and hippocampus ↑ Expression of glial fibrillary acidic protein in astrocytes in the cortex and corpus callosum |
Adachi et al. | 2001 | Bilateral rat renal artery occlusion. Endpoint: 48 h Readout: motor activity and brain monoamine turnover | ↓ Turnover of DA in the striatum, mesencephalon and hypothalamus Impaired motor activity |