Skip to main content

Table 4 Predictors of mortality

From: Neurologic manifestations of COVID-19 in critically ill patients: results of the prospective multicenter registry PANDEMIC

Parameter

A. Influence of disease categories on mortality: multivariable full model

 

B. Influence of diseases on mortality: multivariable full model

Odds ratio

2.5% CI

97.5% CI

p

 

Odds ratio

2.5% CI

97.5% CI

p

(Intercept)

0.00

0.00

0.00

< 0.001

(Intercept)

0.00

0.00

0.00

< 0.001

Cerebrovascular disorder

8.13

3.83

17.26

< 0.001

Acute ischemic stroke

3.89

1.85

8.17

< 0.001

Neuromuscular disorder

0.25

0.09

0.66

0.005

Intracerebral hemorrhage

6.14

2.53

14.89

< 0.001

Encephalopathy

1.29

0.65

2.53

0.466

CIP/CIM

0.21

0.08

0.58

0.003

Inflammatory CNS disorder

0.79

0.04

14.73

0.875

Delirium

0.79

0.37

1.67

0.540

Epileptic disorder

0.77

0.28

2.08

0.607

Inflammatory CNS disorder

0.81

0.05

12.20

0.882

     

Epileptic disorder

1.01

0.38

2.69

0.981

Age (years)

1.06

1.03

1.10

< 0.001

 

1.07

1.04

1.11

< 0.001

Female sex

0.88

0.45

1.70

0.702

 

0.73

0.37

1.44

0.358

Preexisting neurological diseases

0.62

0.28

1.36

0.229

 

0.59

0.27

1.27

0.174

Preexisting cardiovascular diseases

1.24

0.57

2.72

0.584

 

1.27

0.59

2.77

0.538

Vasopressors

6.91

1.81

26.41

0.005

 

6.91

1.84

25.91

0.004

Invasive ventilation

1.07

0.30

3.78

0.921

 

1.03

0.29

3.67

0.958

ARDSa

1.30

0.54

3.16

0.556

 

1.29

0.54

3.10

0.561

Acute kidney failure

1.39

0.67

2.88

0.373

 

1.43

0.69

2.97

0.331

Acute liver failure

4.21

1.60

11.05

0.004

 

4.25

1.63

11.11

0.003

Sepsis

1.69

0.82

3.48

0.153

 

1.41

0.69

2.87

0.348

ECMOa

2.48

1.05

5.85

0.037

 

2.68

1.15

6.23

0.022

pmRS (points)b

1.37

1.07

1.75

0.012

 

1.44

1.12

1.85

0.005

LEOSS stage of disease: complicatedc

1.33

0.47

3.82

0.589

 

1.14

0.43

3.06

0.792

LEOSS stage of disease: criticalc

1.59

0.57

4.48

0.375

 

1.46

0.52

4.10

0.471

Anticoagulant drugs on admission

2.35

1.11

4.96

0.026

 

2.00

0.95

4.21

0.068

Time from COVID-19 diagnosis to first neurologic deficit (days)b

0.97

0.95

1.00

0.027

 

0.97

0.95

1.00

0.025

  1. Bold values are significant (p < 0.05)
  2. A: The influence of categories of disease on mortality was examined in a multivariable logistic regression model adjusted for the variables (age, sex, preexisting neurological disease, preexisting cardiovascular disease, vasopressors, invasive ventilation, ARDS, acute kidney failure, acute liver failure, sepsis, ECMO, pmRS, LEOSS stage of disease complicated and critical, anticoagulant drugs on admission, duration of COVID-19 diagnosis until first neurologic deficit
  3. B: The influence of the most common diseases (like acute ischemic stroke, intracerebral hemorrhage, CIP/CIM and Delirium) on mortality was examined in a multivariable logistic regression model adjusted for the same variables as in Table 4A
  4. ICH: intracerebral hemorrhage, CIP/CIM: critical illness polyneuropathy/myopathy, ARDS: acute respiratory distress syndrome, CNS: central nervous system, ECMO: extracorporeal membrane oxygenation
  5. a88/91 ECMO patients had ARDS. The ECMO variable might act as an indicator for severe ARDS, whereas ARDS without ECMO is likely not as severe
  6. bAge/Duration/mRS were used as continuous covariates; odds ratios are given per point on the respective scale. To get, for example, the estimated odds ratio of 10 years of age, calculate 1.02^(10)
  7. cCompared to LEOSS Stage uncomplicated
Back to article page

Critical Care

ISSN: 1364-8535