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Table 2 ROC curve analyses of responses in terms of lung aeration at each observed session for prediction of treatment success

From: Lung ultrasound response to awake prone positioning predicts the need for intubation in patients with COVID-19 induced acute hypoxemic respiratory failure: an observational study

Variable AUC (95% CI) p Cut-off Sens Spec LR +  LR—
Day 1        
 Δ-Dorsal LUS 0.75 (0.69–0.88)  < 0.001  <  − 1 80 60 2.04 0.33
 Δ-ROX index 0.65 (0.52–0.76) 0.05  > 0.5 55 88 4.67 0.51
 Δ-RR 0.53 (0.41–0.65) 0.67  <  − 1 40 72 1.46 0.83
 Δ-SpO2/FiO2 ratio 0.65 (0.53–0.76) 0.04  > 7 50 84 3.19 0.59
Day 2        
 Δ-Dorsal LUS 0.63 (0.50–0.74) 0.07  <  − 2 78 43 1.39 0.49
 Δ-ROX index 0.75 (0.63–0.84)  < 0.001  > 1.2 89 54 1.98 0.19
 Δ-RR 0.66 (0.53–0.77) 0.02  <  − 1 63 64 1.79 0.57
 Δ-SpO2/FiO2 ratio 0.66 (0.53–0.77) 0.03  > 1.1 47 86 3.45 0.61
Day 3        
 Δ-Dorsal LUS 0.51 (0.39–0.63) 0.86  <  − 2 15 90 1.61 0.93
 Δ-ROX index 0.57 (0.44–0.69) 0.32  > 1.8 100 23 1.31 0
 Δ-RR 0.67 (0.54–0.77) 0.01  <  − 2 26 98 13.4 0.75
 Δ-SpO2/FiO2 ratio 0.60 (0.48–0.72) 0.12  > 15 89 39 1.47 0.27
Whole 3 days        
 Δ-Dorsal LUS 0.72 (0.62–0.84) 0.005  <  − 1 50 82 2.83 0.61
 Δ-ROX index 0.84 (0.73–0.92)  < 0.001  > 0.3 50 90 5.10 0.55
 Δ-RR 0.71 (0.59–0.82) 0.005  < 0 57 84 3.69 0.50
 Δ-SpO2/FiO2 ratio 0.77 (0.64–0.86)  < 0.001  > 42 100 51 2.04 0
  1. Δ-Dorsal LUS change in lung ultrasound score after the APP session; Δ-ROX change in ROX index after the APP session; Δ-RR change in respiratory rate after the APP session; Δ-SpO2/FiO2 ratio change in SpO2/FiO2 ratio after the APP session; AUC area under the curve; Sens sensitivity; Spec specificity; LR + positive likelihood ratio; LR − negative likelihood ratio