Table 1 Patient demographics and baseline characteristics, by study
eStimCycle [25] | EXERCISE [26] | I-SURVIVE [20] | TryCYCLE [24] | CYCLE Pilot RCT [19] | |
|---|---|---|---|---|---|
Enrolled, N | 162 | 150 | 40 | 33 | 66 |
Age | 61.0 (49.0, 67.0) | 60.7 (15.8) | 62.0 (17.0) | 65.8 (12.2) | 61.6 (16.9) |
Female, n(%) | 55 (44.0) | 55 (36.7) | 21 (52.5) | 16 (48.5) | 26 (39.4) |
APACHE II | 22.3 (7.8) | 19.0 (16.0, 23.0) | 20.0 (14.0, 28.0) | 24.3 (6.7) | 23.5 (8.6) |
Admission diagnosis, n (%) | |||||
Respiratory | 65 (40.1) | 34 (22.7) | 7 (17.5) | 19 (57.6) | 36 (54.5) |
Gastrointestinal | 30 (18.5) | 0 (0.0) | 13 (32.5) | 4 (12.1) | 8 (12.1) |
Cardiovascular | 18 (11.1) | 23 (15.3) | 4 (10.0) | 2 (6.1) | 3 (4.5) |
Sepsis | 162 (100.0)□ | 17 (11.3) | 6 (15.0) | 4 (12.1) | 11 (16.7) |
Renal | 0 (0.0) | 7 (4.6) | 1 (2.5) | 1 (3.0) | 2 (3.0) |
Non-pulmonary infection | 12 (7.4) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
Cardiac surgery | 0 (0.0) | 45 (30.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
Other surgery | 0 (0.0) | 31 (20.7) | 0 (0.0) | 2 (6.1) | 0 (0.0) |
Liver disease/transplant | 0 (0.0) | 21 (14.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
Cardiac arrest | 0 (0.0) | 11 (7.3) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
Neurological | 0 (0.0) | 0 (0.0) | 4 (10.0) | 0 (0.0) | 2 (3.0) |
Other | 37 (22.8) | 11 (7.3) | 5 (12.5) | 1 (3.0) | 4 (6.1) |
Charlson Comorbidity Index | 2.0 (0.0, 3.0) | * | * | 2.2 (2.0) | 1.92 (1.6) |
Pre-ICU Katz ADL Score | 6.0 (6.0, 6.0) | * | 6.0 (6.0, 6.0) | 5.5 (1.3) | 5.65 (0.98) |
Duration of MV, days | 6.9 (4.0, 10.8) | 4.1 (2.1, 7.1)• | 4.0 (2.0, 9) | 8.0 (6.0, 14.0) | 8.0 (5.0, 19.0) |
ICU length of stay, days | 10 (7, 17) | 7.0 (6.0, 11.0) | 7.0 (4.0, 2.0) | 11.0 (7.0, 17.0) | 11.0 (8.0, 25.0) |
ICU mortality | 34 (21.0) | * | † | 5 (15.0) | 18 (55.0) |
Hospital length of stay, days | 22.0 (13.0, 39.0) | 22.0 (15.0, 36.0) | 22.0 (16.0, 48.0) | 31.0 (16.0, 42.0) | 25.0 (15.0, 45.0) |
Hospital mortality | 39 (24.0) | * | 2 (5.0) | 10 (30.0) | 22 (67.3) |
Discharge disposition, n(5) | |||||
Home | 74 (60.2) | 84 (56.0) | 25 (65.8) | 13 (56.5) | 30 (68.1) |
Acute rehabilitation | 32 (19.8) | 34 (22.7) | 5 (13.2) | 3 (13.0) | 7 (15.9) |
Acute hospital | 3 (1.9) | 8 (5.3) | 4 (10.5) | 4 (17.4) | 5 (11.4) |
Chronic care | 5 (3.1) | 0 (0.0) | 2 (5.0) | 1 (4.3) | 0 (0.0) |
Other | 48 (29.6) | 24 (16.0) ‡ | 0 (0.0) | 2 (8.7) | 2 (4.5) |