Fig. 2

Trajectory of outcomes to 6 months in patients with sepsis (red) and without sepsis (blue). A–C Circles are mean and error bars are 95% confidence interval. P values calculated from the interaction between sepsis and time from a mixed-effect generalized linear model with Gaussian distribution, including center as random effect, and adjusted by age, sex, ICU admission source, APACHE III score, type of admission (medical vs. surgical), lung transplant patients, trauma, creatinine, heart rate, mean arterial pressure, presence of chronic cardiovascular disease and ICU length of stay. Models were further adjusted by the baseline value of the outcome of interest as fixed effect. D Outcomes assessed at 6 months of follow-up. Boxes represent median and interquartile range. Whiskers extend 1.5 times the interquartile range beyond the first and third quartiles per the conventional Tukey method. Transparent circles beyond the whiskers represent outliers. Abbreviations: WHODAS, WHO Disability Assessment Schedule 2.0; IES-R, Impact of Event Scale–Revised; IADL, instrumental activities of daily living; and MoCA-BLIND, Montreal Cognitive Assessment