Fig. 1

Norepinephrine requirement dose profiles over time. Both curves were obtained after modelling of NE evolution over time of a “controlled” shock (dark blue line with dots) and a “refractory” shock (clear blue line with squares). Both profiles overshot the threshold of 0.5 µg/kg/min of NE dose, but only the “refractory” shock profile would benefit the most of a very early AVP infusion (NE < 0.25 µg/kg/min). AVP: Arginine vasopressin; NE: norepinephrine; and SSC: Surviving Sepsis Campaign