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Table 6 Association between confounders and time to weaning from invasive mechanical ventilation (cox-type model for calorie intake)

From: Medical nutrition therapy and clinical outcomes in critically ill adults: a European multinational, prospective observational cohort study (EuroPN)

 

Variable name

HR

LL CI 95%

UL CI 95%

p value

Predictor variables

Age

1.00

0.99

1.00

0.245

Female vs. male

1.23

0.98

1.55

0.079

Body weight (kg)

1.00

0.99

1.00

0.189

Surgical versus non-surgical ICU admission

1.45

1.12

1.90

0.006

Main reason for ICU admission: Infection (yes vs. no)

1.25

0.99

1.59

0.066

Main reason for ICU admission: Respiratory (yes vs. no)

0.59

0.46

0.75

< 0.001

Number of severe comorbidities

1.13

1.00

1.28

0.046

APACHE II

1.00

0.99

1.01

0.847

Average SOFA score of preceding days (d1–d5)

0.89

0.85

0.92

< 0.001

Sum of preceding days with HAIs (d1–d5)

0.90

0.83

0.97

0.006

Baseline functional status

0.97

0.91

1.03

0.316

% of total calories given via the enteral and oral route (d1–d5)

1.00

1.00

1.01

0.075

Random effect

Study site

   

< 0.001

  1. A HR < 1 indicates a longer time until extubation
  2. APACHE Acute Physiology and Chronic Health Evaluation, ICU intensive care unit, HR hazard ratio, LL lower limit, UL upper Limit, CI confidence interval, HAI hospital acquired infection