Plasma disappearance rate of albumin when infused as a 20% solution

Table 2 Population kinetic parameters for albumin administered as a 20% solution in 70 subjects

Kinetic parameter	Best estimate	95% CI	CV%	T_1/2 (h)
1. Plasma albumin increase only
tvV_c (L)	5.88	5.51–6.26	3.2
tvk (10⁻⁴ min⁻¹)	13.8	9.9–17.6	14.3	8.4 (6.6–11.6)
2. Albumin increase corrected for outliers
tvV_c (L)	5.87	5.50–6.23	3.3
tvk (10⁻⁴ min⁻¹)	10.7	8.2–13.2	12.0	10.8 (8.7–14.1)
Surgery with major hemorrhage, covariate (0/1)^a	2.30	1.88–2.72	9.2
3. Albumin × plasma dilution + compartment for albumin losses
tvV_c (L)	5.11	4.81–5.42	3.1
tvk_b (10⁻⁴ min⁻¹)	5.80	5.04–6.57	6.7	19.9 (17.6–22.9)
tvk_bleed (10⁻⁴ min⁻¹)	5.58	4.82–6.35	7.0
Surgery with major hemorrhage, covariate (0/1)^a	1.37	1.12–1.62	9.3
4. Plasma dilution corrected for bleeding-induced changes in distribution volume
tvV_c (L)	5.17	4.86–5.48	3.0
tvk_b (10⁻⁴ min⁻¹)	7.12	6.04–8.21	7.8	16.2 (14.0–19.1)
tvk_bleed (10⁻⁴ min⁻¹)	5.81	4.82–6.79	8.6
Surgery with major hemorrhage, covariate (0/1)^a	1.38	1.06–1.70	11.7

Four different approaches are shown for the calculation of the intravascular half-life (T_1/2), but only the last two consider the shortening that occurs due to blood sampling and surgery-induced blood loss
tv = typical value for the group. CI = confidence interval. CV% = coefficient of variation (inter-individual)
^aCovariate means that the k_b in that group becomes tvk_b = tvk_b * (2.178 ^ covariate value) and others only tvk_b

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