Dopamine use and its consequences in the intensive care unit: a cohort study utilizing the Japanese Intensive care PAtient Database

Table 2 Multivariable logistic analysis with the generalized estimating equation: predictors of in-hospital mortality

Predictors	Odds ratios	CI
(Intercept)	0.02	0.01–0.03
Age	1.00	1.00–1.01
Male gender	1.04	0.95–1.04
Comorbidities
Acquired immune deficiency syndrome	4.29	2.17–8.48
Congestive heart failure	1.77	1.38–2.28
Respiratory failure	1.44	1.06–1.95
Cirrhosis	1.60	1.22–2.09
Use of immunosuppressants	1.41	1.17–1.70
Hemodialysis	1.40	1.17–1.67
Acute leukemia or lymphoma	1.85	1.28–2.66
Cancer with metastases	1.84	1.36–2.50
Days before ICU after hospital admission	1.01	1.00–1.01
Cardiopulmonary resuscitation prior to ICU admission	1.26	0.98–1.60
Reason for ICU admission (compared to others)
Transfer from the ward	0.79	0.66–0.93
Admission from the emergency room	0.25	0.21–0.31
Admission following elective surgery	0.67	0.56–0.81
Admission following urgent surgery	0.93	0.72–1.19
Diagnosis code (Not stated as reference)
Cardiovascular	0.71	0.56–0.86
Infection	0.73	0.63–0.85
APACHE III score	1.03	1.03–1.03
Serum lactate level	1.05	1.03–1.06
Mechanical ventilation during the first 24 h	0.90	0.78–1.04
Acute kidney injury during the first 24 h	1.51	1.26–1.82
Dobutamine use	1.12	0.96–1.29
Adrenaline use	1.58	1.18–2.12
Dopamine use (compared to no use)
Dopamine (≤ 5 microg/kg/min)	0.86	0.71–1.04
Dopamine (More than 5 but equal to or less than 15 microg/kg/min)	1.46	1.18–1.82
Dopamine (≥ 15 microg/kg/min)	3.30	1.19–9.19

ICU Intensive care unit, APACHE III Acute Physiological Assessment and Chronic Health Evaluation

ISSN: 1364-8535