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Table 3 Sensitivities and specificities for single and combined predictors in the ERC/ESICM algorithm

From: External validation of the 2020 ERC/ESICM prognostication strategy algorithm after cardiac arrest

 

GCS_M ≤ 3

PR/CR

SSEP

EEG

NSE

Poor CT

Poor DWI

A. Unconscious patients at ≥ 72 h after ROSC without confounders

 GCS_M ≤ 3

89.9/69.0 (660)

      

 No PR/CR

64.1/100 (471)

62.86/100 (518)

     

 No SSEP N20

74.8/100 (133)

59.09/100 (122)

72.73/100 (150)

    

 Highly malignant EEG

60.4/100 (224)

45.12/100 (192)

56.63/100 (94)

59.22/100 (249)

   

 NSE 60

81.0/100 (319)

54.17/100 (298)

76.47/100 (95)

60.63/100 (153)

78.83/94.64 (363)

  

 Poor CT

33.6/86.5 (537)

26.3/100 (478)

31.6/100 (135)

26.5/100 (224)

33.5/100 (341)

32.8/90.9 (602)

 

 Poor DWI

83.2/92.0 (298)

58.2/100 (257)

68.5/100 (124)

49.0/100 (178)

76.6/100 (188)

31.7/100 (314)

78.0/100 (332)

B. Unconscious patients with GCS_M ≤ 3 at ≥ 72 h after ROSC without confounders

 No PR/CR

 

64.1/100 (471)

     

 No SSEP N20

 

60.8/100 (111)

74.8/100 (133)

    

 Highly malignant EEG

 

46.3/100 (176)

58.0/100 (85)

60.4/100 (224)

   

 NSE 60

 

55.5/100 (271)

79.3/100 (85)

62.1/100 (137)

81.0/100 (319)

  

 Poor CT

 

27.2/100 (435)

32.7/100 (119)

26.9/100 (201)

34.9/100 (299)

33.6/86.5 (537)

 

 Poor DWI

 

59.7/100 (238)

71.2/100 (110)

50.3/100 (161)

79.6/100 (166)

32.8/100 (281)

79.5/100 (298)

  1. The upper column indicates the sensitivity and specificity as a percentage in order. Parentheses indicate the number of patients tested
  2. ROSC, return of spontaneous circulation; PR, pupillary light reflex; CR, corneal reflex; SSEP, somatosensory evoked potential; EEG, electroencephalogram; NSE, neuron-specific enolase; CT, computed tomography; DWI, diffusion-weighted image