The pathogens of secondary infection in septic patients share a similar genotype to those that predominate in the gut

Table 1 Clinical characteristic of septic and non-septic ICU patients on admission and 7th day in ICU

	Day1			Day7			Septic patients Day1 vs septic patients Day7 P value
	Septic patients (n = 34)	non-septic ICU patients (n = 33)	P value	Septic patients (n = 34)	non-septic ICU patients (n = 33)	P value	Septic patients Day1 vs septic patients Day7 P value
SOFA score	4.5 (4.0, 8.0)	2.0 (0.0, 2.0)	< 0.001	5.0 (3.0, 7.3)	1.0 (0.0, 2.0)	< 0.001	0.848
APACHE II score	13.5 (8.8, 19.5)	7.0 (3.0, 11.0)	< 0.001	11.5 (7.0, 19.3)	6.0 (3.0, 8.0)	< 0.001	0.253
WBC (10⁹/L)	10.9 (6.6, 15.3)	8.0 (5.5, 11.25)	0.077	10.6 (5.5, 16.38)	7.0 (4.9, 8.9)	0.013	0.941
CRP (mg/L)	104.0 (54.8, 204.7)	51.3 (5.0, 11.3)	0.011	32.6 (12.4, 72.0)	9.5 (5.0, 32.8)	0.003	< 0.001
PCT (ng/ml)	1.8 (0.5, 16.0)	0.2 (0.11, 0.71)	< 0.001	0.6 (0.2, 2.2)	0.2 (0.1, 0.4)	0.001	0.015
TNF-α (pg/L)	15.1 (9.5, 23.8)	11.8 (7.0, 18.8)	0.044	13.6 (9.3, 22.6)	7.5 (5.3, 14.9)	0.024	0.522
IL-1β (pg/L)	5.0 (5.0, 5.0)	5.0 (5.0, 5.0)	0.801	5.0 (5.0, 5.0)	5.0 (5.0, 5.2)	0.552	0.94
IL-2R (pg/L)	1519.0 (940.0, 1931.0)	567.0 (416.0, 812.0)	< 0.001	1070.0 (694.5, 1310.0)	528.5 (413.8, 651.5)	0.003	0.011
IL-6 (pg/L)	36.1 (14.4, 89.6)	15.9 (7.5, 36.1)	0.016	18.75 (6.7, 47.0)	8.1 (4.8, 15.8)	0.082	0.027
IL-8 (pg/L)	46.0 (22.0, 90.0)	21.0 (9.0, 44.0)	0.007	34.5 (16.3, 61.5)	15.0 (11.3, 24.0)	0.009	0.228
IL-10 (pg/L)	13.1 (6.7, 31.9)	5.0 (5.0, 6.8)	< 0.001	6.8 (5.0, 15.8)	5.0 (5.0, 6.4)	0.004	0.032

SOFA, Sequential Organ Failure Assessment; APACHE II, Acute Physiology and Chronic Health Evaluation II; WBC, white blood cell; CRP, C-reactive protein; PCT, procalcitonin; TNF-α, tumor necrosis factor-α; IL-1β, interleukin-1β; IL-2R, interleukin-2 receptor; IL-6, interleukin-6; IL-8, interleukin-8; IL-10, interleukin-10.

ISSN: 1364-8535