Table 1 Settings of the data-driven effect size, study heterogeneity and publication bias priors for the primary outcome mortality and secondary outcome unfavourable neurology
Prior description | Risk ratio, mean | Risk ratio, standard deviation |
|---|---|---|
Death | ||
 Minimally informative | Cauchy distribution with location = 1 | NA |
 Informed based on frequentist random effects meta-analysis | 0.95 | 0.04 |
 Strongly enthusiastic based on an RR as targeted in the TTM2 study [17] with a SD similar to the TTM study [40] | 0.86 | 0.07 |
 Moderately enthusiastic based on an RR similar to Lascarrou et al. [41] with a SD similar to the TTM study [40] | 0.98 | 0.07 |
 Moderately sceptic based on an RR = 1 with a SD similar to the TTM study [40] | 1 | 0.07 |
 Strongly sceptic based on an RR = 1 with a SD half that of the TTM study [40] | 1 | 0.035 |
Unfavourable neurological outcome | ||
 Minimally informative | Cauchy distribution with location = 1 | NA |
 Informed based on frequentist random effects meta-analysis | 0.94 | 0.04 |
 Strongly enthusiastic based on an RR as targeted in the TTM2 study [17] with a SD similar to the TTM study [40] | 0.86 | 0.06 |
 Moderately enthusiastic based on an RR similar to Lascarrou et al. [41] with a SD similar to the TTM study [40] | 0.95 | 0.06 |
 Moderately sceptic based on an RR = 1 with a SD similar to the TTM study [40] | 1 | 0.06 |
 Strongly sceptic based on an RR = 1 with a SD half that of the TTM study [40] | 1 | 0.03 |
Based on 14,886 meta-analyses [26]: | Mean | Standard deviation |
|---|---|---|
Between-study heterogeneity (Ï„2) | ||
 Outcome: death | 0.02 | 0.51 |
 Outcome: unfavourable neurological recovery | 0.02 | 1.23 |
Publication biasa | ||
 Two-sided p value < 0.05 | 100% publication rate |  |
 Two-sided p value ≥ 0.05 < 0.10 | 66% publication rate |  |
 Two-sided p value ≥ 0.10 | 33% publication rate |  |