Table 1 Baseline characteristics of COVID-19 and H1N1 patients with ARDS
Variables | COVID-19 N = 146 | H1N1 N = 162 | P value |
|---|---|---|---|
Age, yrs | 53 (48–59) | 47 (37–58) | 0.0003 |
Gender—male, n (%) | 124 (85) | 100 (62) | 0.0001 |
BMI | 29 (26–34) | 29 (25–33) | 0.1938 |
Underlying comorbidities, n (%) | Â | Â | Â |
 Obesity, n (%) | 61 (42) | 68 (43) | 0.825 |
 Arterial hypertension, n (%) | 73 (50) | 44 (27) | 0.0001 |
 Smoking, n (%) | 26 (18) | 29 (18) | 0.983 |
 Diabetes, n (%) | 37 (25) | 23 (14) | 0.014 |
 Asthma, n (%) | 8 (5) | 5 (3) | 0.297 |
 COPD, n (%) | 2 (1) | 8 (5) | 0.078 |
 Pregnancy, n (%) | 2 (1) | 6 (4) | 0.199 |
 Chronic heart failure, n (%) | 3 (2) | 7 (4) | 0.263 |
 Chronic liver disease, n (%) | 4 (3) | 2 (1) | 0.340 |
 Chronic renal failure, n (%) | 4 (3) | 1 (1) | 0.141 |
 Malignancy, n (%) | 2 (1) | 7 (4) | 0.125 |
 Chronic immunosuppression, n (%) | 8 (5) | 3 (2) | 0.087 |
SOFA | 7 (5–9) | 8 (6–11) | 0.0017 |
SAPS II | 35 (27–49) | 35 (27–47) | 0.5591 |
X-ray quadrants involved, n | 4 (4–4) | 4 (3–4) | 0.0004 |
Hospital days before ECMO | 11 (6–17) | 4 (2–8) | 0.0001 |
ICU days before ECMO | 7 (3–12) | 0 (0–3) | 0.0001 |
Days of IMV before ECMO | 5(2–9) | 2(1–6) | 0.0001 |
Rescue therapies pre-ECMO, n (%) | |||
 Lung recruitment maneuvers | 104 (65) | 88 (73) | 0.168 |
 Prone Position | 111 (78) | 57 (35) | 0.0001 |
 Inhaled nitric oxide | 51 (36) | 24 (15) | 0.0001 |
Ventilation setting and ABG pre-ECMO | |||
 PaO2/FiO2, mmHg | 66 (56–80) | 64 (54–82) | 0.3373 |
 PaCO2, mmHg | 59 (51–74) | 56 (48–68) | 0.0492 |
 pH | 7.34 (7.25–7.39) | 7.33 (7.28–7.39) | 0.9772 |
 FiO2 | 1 (0.95–1) | 1 (1–1) | 0.0104 |
 PEEP, cmH2O | 12 (10–14) | 15 (14–18) | 0.0001 |
 VT/PBW, ml | 6 (5–7) | 6 (6–7) | 0.0237 |
 RR, bpm | 25 (22–30) | 26 (20–33) | 0.0821 |
 Pplat, cmH2O | 29 (26–31) | 31 (29–33) | 0.0001 |
 Driving Pressure, cmH2O | 16 (13–19) | 15 (13–18) | 0.0515 |
 Compliance respiratory system, ml/cmH2O | 26 (21–34) | 29 (21–36) | 0.126 |