Table 1 Baseline characteristics of patients stratified by timing of start of antimicrobial treatment
Variable | No. of patients with complete data | All patients (N = 4792) | Timing of antimicrobial therapy | ||
|---|---|---|---|---|---|
Within 1 h (N = 1311) | More than 1 h (N = 3481) | p value | |||
Time to beginning of antimicrobial therapy (minutes) | 4792 | 150 [60, 378.5] | 30 [15, 50] | 240 [120, 518] | – |
Age | 4791 | 70 [59, 77] | 71 [60, 77] | 70 [59, 77] | 0.435 |
Sex: male | 4792 | 2986 (62.3%) | 800 (61%) | 2186 (62.8%) | 0.27 |
Origin of infection: Community acquired | 4791 | 2273 (47.4%) | 779 (59.4%) | 1494 (42.9%) | ≤ 0.001 |
Nosocomial (ICU/IMC) | 1112 (23.2%) | 208 (15.9%) | 904 (26%) | ||
Nosocomial (general ward) | 1406 (29.3%) | 324 (24.7%) | 1082 (31.1%) | ||
Location at onset of sepsis: ICU | 4792 | 2233 (46.6%) | 559 (42.6%) | 1674 (48.1%) | ≤ 0.001 |
Emergency department | 948 (19.8%) | 333 (25.4%) | 615 (17.7%) | ||
Operating room | 428 (8.9%) | 167 (12.7%) | 261 (7.5%) | ||
General ward | 692 (14.4%) | 127 (9.7%) | 565 (16.2%) | ||
Ambulance service | 211 (4.4%) | 48 (3.7%) | 163 (4.7%) | ||
IMC | 280 (5.8%) | 77 (5.9%) | 203 (5.8%) | ||
Focus of infection: respiratory | 4789 | 2057 (43%) | 510 (38.9%) | 1547 (44.5%) | ≤ 0.001 |
Focus of infection: abdominal | 4789 | 1657 (34.6%) | 464 (35.4%) | 1193 (34.3%) | 0.474 |
Focus of infection: urogenital | 4789 | 695 (14.5%) | 209 (16%) | 486 (14%) | 0.089 |
Focus of infection: bones/soft tissue/wound | 4789 | 531 (11.1%) | 154 (11.8%) | 377 (10.8%) | 0.38 |
Focus of infection: other/unknown | 4789 | 644 (13.4%) | 161 (12.3%) | 483 (13.9%) | 0.154 |
Infection microbiologically confirmed | 4781 | 3514 (73.5%) | 965 (73.7%) | 2549 (73.4%) | 0.854 |
Bacteremia: Gram positive | 4754 | 806 (17%) | 223 (17.2%) | 583 (16.9%) | 0.005 |
Gram negative | 712 (15%) | 226 (17.4%) | 486 (14.1%) | ||
Other/several | 166 (3.5%) | 41 (3.2%) | 125 (3.6%) | ||
No pathogen detected | 2281 (48%) | 627 (48.3%) | 1654 (47.9%) | ||
No blood culture taken | 789 (16.6%) | 182 (14%) | 607 (17.6%) | ||
Vasopressor use within 12 h after first organ dysfunction | 4781 | 3595 (75.2%) | 982 (75.2%) | 2613 (75.2%) | 1 |