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Table 2 Global hemodynamic and tissue perfusion parameters before and 1 h after vitamin C infusion

From: Vitamin C improves microvascular reactivity and peripheral tissue perfusion in septic shock patients

Parameters, median (IQR) H0 H1 p value
Blood pressure (mmHg)
Systolic 107 (100–120) 111 (102–121) 0.43
Diastolic 54 (51–61) 58 (53–62) 0.18
Mean 71 (66–75) 72 (66–77) 0.07
Heart rate (/min) 107 (101–111) 107 (101–110) 0.67
Mottling score 1 (0–3) 1 (0–2) 0.06
Capillary refill time (s)
Index 2.1 (1.7–3.5) 2 (1.2–3) 0.0003
Knee 3.7 (2.6–5.5) 2.9 (1.9–4.7) < 0.0001
Cardiac output (L/min) 4.1 (3.3–4.5) 4 (3.1–4.3) 0.0376
Skin temperature 31.2 (30.2–32.3) 32.2 (31–33.7) < 0.0001
Central-to-skin gradient temperature 6.1 (4.9–7.4) 4.6 (3.4–7.0) < 0.0001
Norepinephrine dose (µg/kg min) 0.6 (0.3–1.2) 0.6 (0.3–1.1) 0.46
  1. Bold was used when p value was ≤ 0.05