Characteristic | Before IPW | After IPWc | ||||
---|---|---|---|---|---|---|
Awake-prone positioning (n = 187) | Non-prone positioning (n = 148) | Standardized difference | Awake-prone positioning (n = 186) | Non-prone positioning (n = 147) | Standardized difference | |
Demographics | ||||||
Age, years, median (p 25–75) | 57 (47–66) | 66.5 (56.5–75) | − 0.58 | 60 (49–68) | 62 (53–75) | − 0.07 |
Female, sex, n (%) | 45 (24) | 41 (28) | − 0.09 | 43 (23) | 37 (25) | − 0.03 |
Body mass index | 30 (27.5–33) | 30.0 (26.8–33.1) | − 0.04 | 30.3 (28.4–34) | 30 (27–33) | 0.04 |
Comorbidities, n (%) | ||||||
Respiratory | 22 (12) | 22 (15) | − 0.07 | 24 (13) | 19 (13) | 0.02 |
Cardiovascular | 41 (22) | 43 (29) | − 0.15 | 48 (26) | 44 (30) | − 0.03 |
Renal | 8 (4,2) | 9 (6) | − 0.10 | 14 (7.7) | 8 (5.6) | − 0.03 |
Hepatic | 4 (2) | 1 (0.6) | 0.12 | 3 (1,6) | 3 (2) | − 0.06 |
Oncohematologic | 2 (1) | 13 (9) | − 0.38 | 6 (3.5) | 9 (6) | − 0.05 |
Solid neoplasm | 2 (1) | 4 (2.7) | − 0.12 | 2 (1) | 2 (1.35) | − 0.04 |
Immunosuppression | 6 (3) | 10 (6.7) | − 0.13 | 10 (5.4) | 5 (3.3) | − 0.03 |
Neurologic | 6 (3) | 8 (5.4) | − 0.10 | 5 (2.5) | 4 (2.9) | − 0.04 |
Diabetes | 40 (21) | 43 (29) | − 0.19 | 55 (29.5) | 41 (28) | − 0.04 |
Hypertension | 62 (33) | 80 (54) | − 0.43 | 70 (37.2) | 73 (50) | − 0.07 |
Smoking | 50 (27) | 53 (36) | − 0.20 | 51 (27.3) | 41 (28) | − 0.01 |
Chronology | ||||||
Days from symptom onset to hospital admission, median (p25–75) | 8 (6–10) | 8.0 (5–10) | 0.01 | 8 (6–10) | 9 (5–11) | − 0.05 |
Previous days of oxygen therapy, median (p25–75) | 1 (0–2) | 1 (1–3) | − 0.26 | 1 (0–3) | 1 (0–3) | 0.003 |
Laboratory at admission | ||||||
CRP, mg/dl, median (p 25–75) | 10.7 (5.1–18) | 9.26 (5–17) | − 0.05 | 9.7 (5–16) | 8.6 (5–17) | − 0.002 |
Respiratory-hemodynamics, and scores at admission | ||||||
APACHE score, median (p 25–75) | 10 (7–12) | 10 (8–13) | − 0.22 | 10 (6–13) | 10 (7–13) | − 0.10 |
SOFA score, median (p 25–75) | 3 (2–4) | 3 (2–4) | 0.02 | 3 (2–4) | 3 (2–4) | − 0.05 |
CT scored, median (p 25–75) | 13 (9–17) | 13 (10–15) | 0.12 | 13 (9–17) | 13 (10–15) | 0.01 |
ROX index, median (p 25–75) | 6.6 (4.7–11) | 6 (4.1–8.3) | 0.39 | 6.3 (4.8–9.5) | 5.6 (4.2–8.3) | 0.10 |
Treatments | ||||||
Antibiotics, n (%) | 150 (80) | 133 (90) | − 0.28 | 158 (85) | 128 (87) | − 0.07 |
Systemic corticosteroids, n (%) | 185 (99) | 145 (98) | 0.08 | 184 (99) | 146 (99) | 0.03 |
Light sedation, n (%) | 116 (62) | 46 (31) | 0.65 | 90 (48) | 66 (45) | 0.03 |
Oxygen therapy previous to ICU-admission (mode)b | 1.68 | 1.71 | − 0.07 | 1.78 | 1.75 | − 0.02 |