Table 1 Characteristics of the studies included in the analysis
Study | Guervilly et al. [6] | Garcia et al. [5] | Rilinger et al. [7] | Giani et al. [3] | Petit et al. [4] |
|---|---|---|---|---|---|
Design | Monocentric retrospective cohort study | Monocentric retrospective cohort study | Monocentric retrospective cohort study | Multicentric retrospective cohort study | Monocentric retrospective cohort study |
Country | France | France | Germany | Italy | France |
Case volume# of the ECMO centers, runs/year (V-V runs) | 55 (50) | 45 (25) | 125 (35) | 35–55 (25–33)& | 450 (60) |
Total number of patients (Prone group) | 168 (91) | 25 (14) | 158 (38) | 240 (107) | 298 (64) |
Population | ARDS patients on | COVID-19 ARDS patients on V-V ECMO | ARDS patients on V-V ECMO | ARDS patients on V-V ECMO | ARDS patients on V-V ECMO |
Prone positioning duration | 16 (12–16) hours | 16 (15–17) hours | 20 (17–21) hours | 15 (12–18) hours | 16 (16–16) hours |
Statistics | Univariable analysis, individual matching | Univariable analysis | Multivariable analysis, propensity score matching | Multivariable analysis, propensity score matching | Propensity score matching |
Outcome | |||||
Last follow-up | 90 days | 28 days | Hospital discharge | Hospital discharge | 90 days |
Mortality, Prone vs Supine group | 36% vs 58%* | 79% vs 27%° | 63% vs 63%* | 30% vs 53%* | 25% vs 46%* |