Endotheliopathy is associated with slower liberation from mechanical ventilation: a cohort study

Table 2 30-day absolute risk of liberation from mechanical ventilation and of the competing risk of death on mechanical ventilation in mechanically ventilated patients in the intensive care unit—results from competing risks Cox regression (n = 459)

	30-day absolute risk (95% CI)^a
	Liberation from mechanical ventilation		Death on mechanical ventilation
Biomarker^†	25th percentile	75th percentile	25th percentile	75th percentile
Syndecan-1	0.84 (0.74–0.9)	0.81 (0.7–0.88)	0.13 (0.07–0.2)	0.17 (0.1–0.26)
sTM	0.85 (0.76–0.91)	0.76 (0.62–0.85)	0.12 (0.07–0.2)	0.19 (0.1–0.29)
PECAM-1	0.85 (0.76–0.91)	0.78 (0.66–0.86)	0.12 (0.06–0.19)	0.18 (0.11–0.28)

^aThe absolute risks are calculated for a 71-year old female, with no chronic obstructive pulmonary disease, no chronic heart failure, no respiratory infection at baseline, no acute kidney injury at baseline, with a Bilirubin of 10.7 µmol/L at baseline and a PaO₂/FiO₂-ratio of 21.4 kPa at baseline
^†Biomarkers were analyzed as continuous variables and the absolute risks associated with values at the 25th and the 75th percentile are presented: 21.0 and 118.4 ng/ml (Syndecan-1), 5.0 and 18.0 ng/ml (soluble Thrombomodulin [sTM]), 11.1 and 14.6 ng/ml (Platelet Endothelial Cell Adhesion Molecule-1 [PECAM-1]). 95% CI 95% confidence interval

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