Respiratory effects of lung recruitment maneuvers depend on the recruitment-to-inflation ratio in patients with COVID-19-related acute respiratory distress syndrome

Table 1 General characteristics of the study population

Parameters	n (%) Median [IQR]
Demographic data
Sex, male	23 (77)
Age, years	67 [58–74]
BMI, kg/m²	33 [29–38]
Computed tomography findings
Diffuse pattern	24 (100)
Interstitial syndrome	24 (100)
Alveolar consolidation	15 (63)
Lung damage extension, %	50 [28–71]
Gas exchange
VR	2.07 [1.61–2.51]
P_aO₂/F_iO₂, mmHg	105 [86–133]
Severe ARDS	12 (40)
Respiratory mechanics
Tidal volume, ml/kg PBW	6.1 [5.9–6.3]
Respiratory rate, breaths/min	28 [25–30]
Plateau pressure, cmH₂O	26 [23–28]
PEEP applied, cmH₂O	13 [8–16]
C_rs, mL/cmH₂O	33 [26–42]
Airway closure	15 (50)
R/I ratio	0.62 [0.42–0.83]
Death in the ICU	14 (46)

AOP: airway opening pressure, ARDS: acute respiratory distress syndrome, BMI: body mass index, C_rs: respiratory system compliance, ICU: intensive care unit, IQR: interquartile range, P_aO₂/F_iO₂: partial pressure of oxygen to inspired oxygen fraction, PEEP: positive end-expiratory pressure, R/I: recruitment-to-inflation, VR: ventilator ratio

ISSN: 1364-8535