Table 2 Histopathologic features of different clusters
From: Lung histopathologic clusters in severe COVID-19: a link between clinical picture and tissue damage
Cluster 1 N = 9 | Cluster 2 N = 34 | Cluster 3 N = 12 | Cluster 4 N = 19 | Cluster 5 N = 1 | p value* | |
|---|---|---|---|---|---|---|
Early proliferative DAD | 10 (5–10) | 9 (7–10) | 9.5 (7.5–10) | 0 (0–1) | 0 | < 0.001 |
Megakaryocytes | 10 (5–10) | 6 (5–9.5) | 5.5 (5–6.25) | 5 (4–7) | 0 | 0.076 |
Normal lung areas | 0 (0–0) | 0 (0–0) | 0 (0–0) | 7 (6.5–10.5) | 15 | < 0.001 |
Late proliferative DAD | 0 (0–0) | 1 (0–3) | 9 (6.75–11.5) | 0 (0–0) | 0 | < 0.001 |
Bronchopneumonia | 9 (8–10) | 0 (0–4) | 2 (0.75–2.25) | 1 (0–5) | 0 | < 0.001 |
Interstitial pneumonia | 5 (0–5) | 5 (4–5.75) | 5 (5–5) | 4 (0–5) | 5 | 0.017 |
Thrombi | 4 (2–6) | 3 (3–5) | 0.5 (0–3) | 0 (0–2.5) | 15 | 0.003 |
Exudative DAD | 1 (0–2) | 5 (4–7) | 1 (0.75–3.25) | 2 (0.5–3) | 0 | < 0.001 |
AFOP | 0 (0–2) | 0 (0–1) | 0 (0–1) | 0 (0–0) | 0 | 0.085 |