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Table 1 Baseline characteristics of patients with and without HSV reactivations

From: HSV-1 reactivation is associated with an increased risk of mortality and pneumonia in critically ill COVID-19 patients

   All patients (n = 153) Without HSV reactivation (n = 113) HSV reactivation (n = 40) p-value
Female Number (%) 38 (24.8) 28 (24.8) 10 (25) 1.000
Age Median (IQR) 60.8 [50.2; 69.5] 60.8 [50.1; 68.8] 61.9 [50.9; 70.8] 0.546
BMI Median (IQR) 28.8 [25.3; 33] 29 [25.4; 33] 27.7 [24.4; 33.2] 0.629
Diabetes Number (%) 48 (31.4) 40 (35.4) 8 (20) 0.078
Other chronic diseases* Number (%) 73 (47.7) 55 (48.7) 18 (45) 0.716
SOFA score Median (IQR) 5 [3; 7] 5 [3; 7] 5 [4; 7] 0.468
Maximal body temperature (°C) Median (IQR) 38.2 [37.5; 39.1] 38 [37.5; 39] 38.9 [37.8; 39.3] 0.029
Mechanical ventilation      0.009
None Number (%) 16 (10.5) 14 (12.4) 2 (5)  
CPAP/HFNO Number (%) 85 (55.6) 69 (61.1) 16 (40)  
IMV/PEEP < 10 mmHg Number (%) 0 0 0  
IMV/PEEP > 10 mmHg Number (%) 40 (26.1) 22 (19.5) 18 (45)  
ECMO Number (%) 12 (7.8) 8 (7.1) 4 (10)  
Lymphocytes count (/mm3) Median (IQR) 885 [595; 1220] 890 [610; 1230] 880 [570; 1210] 0.784
Initial use of corticosteroid Number (%) 108 (70.6) 86 (76.1) 22 (55) 0.016
Tocilizumab/anakinra Number (%) 31 (20.3) 25 (22.1) 6 (15) 0.492
CRP (mg/L) Median (IQR) 138.5 [77.5; 204.5] 125 [64.5; 183.5] 180.5 [115.5; 252.5] 0.001
D-Dimers (mg/mL) Median (IQR) 962 [588; 2043] 952 [564; 1768] 1056.5 [682; 4376] 0.195
Ferritin (ng/mL) Median (IQR) 1159 [592; 1979] 1060 [526; 1915] 1348 [832; 2370] 0.110
LDH (UI/L) Median (IQR) 438.5 [337; 606.9] 417 [331; 538] 504.9 [388; 695] 0.019
  1. HSV-positive and -negative patients were compared with Chi-square, Fisher and Wilcoxon tests IQR Inter Quartile Range. These data were collected on ICU admission (day one or two)
  2. HSV Herpes simplex virus; BMI Body Mass Index; SOFA Sequential Organ Failure Assessment; CPAP Continuous Positive Airway Pressure; HFNO High-Flow Nasal Oxygenotherapy; IMV Invasive Mechanical Ventilation; PEEP Positive End Expiratory Pressure; ECMO Extra-Corporeal Membrane Oxygenation; CRP C Reactive Protein; LDH Lactate Dehydrogenase
  3. *Other chronic diseases were hepatic, heart, respiratory, renal or hematologic diseases, according to the Knaus definitions
  4. HSV-positive and -negative patients were compared with Chi-square, Fisher and Wilcoxon tests IQR Inter Quartile Range. These data were collected on ICU admission (day one or two)
  5. HSV Herpes simplex virus; BMI Body Mass Index; SOFA Sequential Organ Failure Assessment; CPAP Continuous Positive Airway Pressure; HFNO High-Flow Nasal Oxygenotherapy; IMV Invasive Mechanical Ventilation; PEEP Positive End Expiratory Pressure; ECMO Extra-Corporeal Membrane Oxygenation; CRP C Reactive Protein; LDH Lactate Dehydrogenase
  6. *Other chronic diseases were hepatic, heart, respiratory, renal or hematologic diseases, according to the Knaus definitions