| | |
All patients (n = 153)
|
Without HSV reactivation (n = 113)
|
HSV reactivation (n = 40)
|
p-value
|
|---|
|
Female
|
Number (%)
|
38 (24.8)
|
28 (24.8)
|
10 (25)
|
1.000
|
|
Age
|
Median (IQR)
|
60.8 [50.2; 69.5]
|
60.8 [50.1; 68.8]
|
61.9 [50.9; 70.8]
|
0.546
|
|
BMI
|
Median (IQR)
|
28.8 [25.3; 33]
|
29 [25.4; 33]
|
27.7 [24.4; 33.2]
|
0.629
|
|
Diabetes
|
Number (%)
|
48 (31.4)
|
40 (35.4)
|
8 (20)
|
0.078
|
|
Other chronic diseases*
|
Number (%)
|
73 (47.7)
|
55 (48.7)
|
18 (45)
|
0.716
|
|
SOFA score
|
Median (IQR)
|
5 [3; 7]
|
5 [3; 7]
|
5 [4; 7]
|
0.468
|
|
Maximal body temperature (°C)
|
Median (IQR)
|
38.2 [37.5; 39.1]
|
38 [37.5; 39]
|
38.9 [37.8; 39.3]
|
0.029
|
|
Mechanical ventilation
| | | | |
0.009
|
|
None
|
Number (%)
|
16 (10.5)
|
14 (12.4)
|
2 (5)
| |
|
CPAP/HFNO
|
Number (%)
|
85 (55.6)
|
69 (61.1)
|
16 (40)
| |
|
IMV/PEEP < 10 mmHg
|
Number (%)
|
0
|
0
|
0
| |
|
IMV/PEEP > 10 mmHg
|
Number (%)
|
40 (26.1)
|
22 (19.5)
|
18 (45)
| |
|
ECMO
|
Number (%)
|
12 (7.8)
|
8 (7.1)
|
4 (10)
| |
|
Lymphocytes count (/mm3)
|
Median (IQR)
|
885 [595; 1220]
|
890 [610; 1230]
|
880 [570; 1210]
|
0.784
|
|
Initial use of corticosteroid
|
Number (%)
|
108 (70.6)
|
86 (76.1)
|
22 (55)
|
0.016
|
|
Tocilizumab/anakinra
|
Number (%)
|
31 (20.3)
|
25 (22.1)
|
6 (15)
|
0.492
|
|
CRP (mg/L)
|
Median (IQR)
|
138.5 [77.5; 204.5]
|
125 [64.5; 183.5]
|
180.5 [115.5; 252.5]
|
0.001
|
|
D-Dimers (mg/mL)
|
Median (IQR)
|
962 [588; 2043]
|
952 [564; 1768]
|
1056.5 [682; 4376]
|
0.195
|
|
Ferritin (ng/mL)
|
Median (IQR)
|
1159 [592; 1979]
|
1060 [526; 1915]
|
1348 [832; 2370]
|
0.110
|
|
LDH (UI/L)
|
Median (IQR)
|
438.5 [337; 606.9]
|
417 [331; 538]
|
504.9 [388; 695]
|
0.019
|
- HSV-positive and -negative patients were compared with Chi-square, Fisher and Wilcoxon tests IQR Inter Quartile Range. These data were collected on ICU admission (day one or two)
- HSV Herpes simplex virus; BMI Body Mass Index; SOFA Sequential Organ Failure Assessment; CPAP Continuous Positive Airway Pressure; HFNO High-Flow Nasal Oxygenotherapy; IMV Invasive Mechanical Ventilation; PEEP Positive End Expiratory Pressure; ECMO Extra-Corporeal Membrane Oxygenation; CRP C Reactive Protein; LDH Lactate Dehydrogenase
- *Other chronic diseases were hepatic, heart, respiratory, renal or hematologic diseases, according to the Knaus definitions
- HSV-positive and -negative patients were compared with Chi-square, Fisher and Wilcoxon tests IQR Inter Quartile Range. These data were collected on ICU admission (day one or two)
- HSV Herpes simplex virus; BMI Body Mass Index; SOFA Sequential Organ Failure Assessment; CPAP Continuous Positive Airway Pressure; HFNO High-Flow Nasal Oxygenotherapy; IMV Invasive Mechanical Ventilation; PEEP Positive End Expiratory Pressure; ECMO Extra-Corporeal Membrane Oxygenation; CRP C Reactive Protein; LDH Lactate Dehydrogenase
- *Other chronic diseases were hepatic, heart, respiratory, renal or hematologic diseases, according to the Knaus definitions
