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Table 2 The risk factors for hospital mortality in univariate logistic regression analysis among SCAP patients with T2DM in training set

From: Clinical characteristics and risk factors associated with mortality in patients with severe community-acquired pneumonia and type 2 diabetes mellitus

Variables Survival (n = 568) Death (n = 315) OR (95%CI) P value
Age 65 (53.74) 71 (59.79) 1.202 (1.089, 1.328) (per increased 10 years old) < 0.001
Number of comorbidities
 0 369 (65) 110 (34.9) Ref  
 1 159 (28) 134 (42.5) 2.827 (2.067, 3.867) < 0.001
 2 38 (6.7) 61 (19.4) 5.385 (3.408, 8.510) < 0.001
 ≥ 3 2 (0.4) 10 (3.2) 16.773 (3.621, 77.695) < 0.001
Diabetes-related complications
 0 504 (88.7) 247 (78.4) Ref  
 1 56 (9.9) 43 (13.7) 1.567 (1.024, 2.398) 0.039
 ≥ 2 8 (1.4) 25 (7.9) 6.377 (2.835, 14.342) < 0.001
Cough
 No 435 (76.6) 190 (60.3) Ref  
 Yes 133 (23.4) 125 (39.7) 2.152 (1.598, 2.898)  < 0.001
Dyspnea
 No 499 (87.9) 238 (75.6) Ref  
 Yes 69 (12.1) 77 (24.4) 2.340 (1.633, 3.353) < 0.001
Blood pressure (mmHg)
 ≥ 90/60 479 (84.3) 201 (63.8) Ref  
 < 90/60 89 (15.7) 114 (36.2) 3.052 (2.211, 4.214) < 0.001
Heart rate (beat/min)
 < 100 332 (58.5) 145 (46) Ref  
 ≥ 100 236 (41.5) 170 (54) 1.649 (1.250, 2.177) < 0.001
CRP (mg/L)
 < 10 199 (35) 24 (7.6) Ref  
 10–99 234 (41.2) 106 (33.7) 3.756 (2.320, 6.080) < 0.001
 100–199 97 (17.1) 78 (24.8) 6.668 (3.972, 11.191) < 0.001
 ≥ 200 38 (6.7) 107 (34) 23.348 (13.304, 40.975) < 0.001
NLR
 < 7 317 (55.8) 86 (27.3) Ref  
 7–19 226 (39.8) 142 (45.1) 2.316 (1.686, 3.182) < 0.001
 ≥ 20 25 (4.4) 87 (27.6) 12.827 (7.745,21.246) < 0.001
BNP (pg/mL)
 < 500 365 (64.3) 58 (18.4) Ref  
 500–4999 149 (26.2) 123 (39) 5.195 (3.604, 7.489) < 0.001
 ≥ 5000 54 (9.5) 134 (42.5) 15.616 (10.259, 23.772) < 0.001
Lactate (mmol/L)
 < 1 213 (37.5) 50 (15.9) Ref  
 1–1.6 244 (43) 85 (27) 1.484 (1.00, 2.202) 0.05
 ≥ 1.7 111 (19.5) 180 (57.1) 6.908 (4.685, 10.186) < 0.001
Platelet (×109/L)
 ≥ 100 463 (81.5) 215 (68.3) Ref  
 < 100 105 (18.5) 100 (31.7) 2.051 (1.492, 2.819) < 0.001
Procalcitonin (µg/L)
 < 0.5 349 (61.4) 146 (46.3) Ref  
 0.5–1.9 112 (19.7) 77 (24.4) 1.643 (1.160,2.329) 0.005
 ≥ 2 107 (18.8) 92 (29.2) 2.055 (1.464,2.885) < 0.001
APTT (s)
 < 37 402 (70.8) 199 (63.2) Ref  
 ≥ 37 166 (29.2) 116 (36.8) 1.412(1.054,1.890) 0.021
AST (IU/L)
 < 35 333 (58.6) 161 (51.1) Ref  
 ≥ 35 235 (41.4) 154 (48.9) 1.355 (1.028, 1.788) 0.031
Creatinine (µmol/L)
 < 100 362(63.7) 173(54.9) Ref  
 ≥ 100 206(36.3) 142(45.1) 1.442(1.090,1.909) 0.010
BUN (mmol/L)
 < 7 253 (44.5) 90 (28.6) Ref  
 ≥ 7 315 (55.5) 225 (71.4) 2.008 (1.495, 2.697) < 0.001
  1. Data are shown as median with number with percentage for categorical variables
  2. SCAP Severe community-acquired pneumonia, n numbers, OR odds ratio, 95% CI 95% confidence interval, CRP C-reactive protein, NLR neutrophil to lymphocyte ratio, BNP brain natriuretic peptide, APTT activated partial thromboplastin time, AST aspartate aminotransferase, BUN blood urea nitrogen, Ref reference