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Table 2 The risk factors for hospital mortality in univariate logistic regression analysis among SCAP patients with T2DM in training set

From: Clinical characteristics and risk factors associated with mortality in patients with severe community-acquired pneumonia and type 2 diabetes mellitus

Variables

Survival (n = 568)

Death (n = 315)

OR (95%CI)

P value

Age

65 (53.74)

71 (59.79)

1.202 (1.089, 1.328) (per increased 10 years old)

< 0.001

Number of comorbidities

 0

369 (65)

110 (34.9)

Ref

 

 1

159 (28)

134 (42.5)

2.827 (2.067, 3.867)

< 0.001

 2

38 (6.7)

61 (19.4)

5.385 (3.408, 8.510)

< 0.001

 ≥ 3

2 (0.4)

10 (3.2)

16.773 (3.621, 77.695)

< 0.001

Diabetes-related complications

 0

504 (88.7)

247 (78.4)

Ref

 

 1

56 (9.9)

43 (13.7)

1.567 (1.024, 2.398)

0.039

 ≥ 2

8 (1.4)

25 (7.9)

6.377 (2.835, 14.342)

< 0.001

Cough

 No

435 (76.6)

190 (60.3)

Ref

 

 Yes

133 (23.4)

125 (39.7)

2.152 (1.598, 2.898)

 < 0.001

Dyspnea

 No

499 (87.9)

238 (75.6)

Ref

 

 Yes

69 (12.1)

77 (24.4)

2.340 (1.633, 3.353)

< 0.001

Blood pressure (mmHg)

 ≥ 90/60

479 (84.3)

201 (63.8)

Ref

 

 < 90/60

89 (15.7)

114 (36.2)

3.052 (2.211, 4.214)

< 0.001

Heart rate (beat/min)

 < 100

332 (58.5)

145 (46)

Ref

 

 ≥ 100

236 (41.5)

170 (54)

1.649 (1.250, 2.177)

< 0.001

CRP (mg/L)

 < 10

199 (35)

24 (7.6)

Ref

 

 10–99

234 (41.2)

106 (33.7)

3.756 (2.320, 6.080)

< 0.001

 100–199

97 (17.1)

78 (24.8)

6.668 (3.972, 11.191)

< 0.001

 ≥ 200

38 (6.7)

107 (34)

23.348 (13.304, 40.975)

< 0.001

NLR

 < 7

317 (55.8)

86 (27.3)

Ref

 

 7–19

226 (39.8)

142 (45.1)

2.316 (1.686, 3.182)

< 0.001

 ≥ 20

25 (4.4)

87 (27.6)

12.827 (7.745,21.246)

< 0.001

BNP (pg/mL)

 < 500

365 (64.3)

58 (18.4)

Ref

 

 500–4999

149 (26.2)

123 (39)

5.195 (3.604, 7.489)

< 0.001

 ≥ 5000

54 (9.5)

134 (42.5)

15.616 (10.259, 23.772)

< 0.001

Lactate (mmol/L)

 < 1

213 (37.5)

50 (15.9)

Ref

 

 1–1.6

244 (43)

85 (27)

1.484 (1.00, 2.202)

0.05

 ≥ 1.7

111 (19.5)

180 (57.1)

6.908 (4.685, 10.186)

< 0.001

Platelet (×109/L)

 ≥ 100

463 (81.5)

215 (68.3)

Ref

 

 < 100

105 (18.5)

100 (31.7)

2.051 (1.492, 2.819)

< 0.001

Procalcitonin (µg/L)

 < 0.5

349 (61.4)

146 (46.3)

Ref

 

 0.5–1.9

112 (19.7)

77 (24.4)

1.643 (1.160,2.329)

0.005

 ≥ 2

107 (18.8)

92 (29.2)

2.055 (1.464,2.885)

< 0.001

APTT (s)

 < 37

402 (70.8)

199 (63.2)

Ref

 

 ≥ 37

166 (29.2)

116 (36.8)

1.412(1.054,1.890)

0.021

AST (IU/L)

 < 35

333 (58.6)

161 (51.1)

Ref

 

 ≥ 35

235 (41.4)

154 (48.9)

1.355 (1.028, 1.788)

0.031

Creatinine (µmol/L)

 < 100

362(63.7)

173(54.9)

Ref

 

 ≥ 100

206(36.3)

142(45.1)

1.442(1.090,1.909)

0.010

BUN (mmol/L)

 < 7

253 (44.5)

90 (28.6)

Ref

 

 ≥ 7

315 (55.5)

225 (71.4)

2.008 (1.495, 2.697)

< 0.001

  1. Data are shown as median with number with percentage for categorical variables
  2. SCAP Severe community-acquired pneumonia, n numbers, OR odds ratio, 95% CI 95% confidence interval, CRP C-reactive protein, NLR neutrophil to lymphocyte ratio, BNP brain natriuretic peptide, APTT activated partial thromboplastin time, AST aspartate aminotransferase, BUN blood urea nitrogen, Ref reference
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