Fever and hypothermia represent two populations of sepsis patients and are associated with outside temperature

Table 2 Predictors of body temperature groups—multinominal logistic regression

Variable	Hypothermia ≤ 36.5 °C	Normothermia 35.6–37.5 °C	Mild fever 37.6–39 °C	High fever ≥ 39.1 °C
Pathogen in BC	0.96 (0.80–1.17)	0.79 (0.67–0.93)^**	Reference category	1.74 (1.46–2.08)^***
Origin of infection
Community	1.37 (1.13–1.66)^**	1.09 (0.92–1.28)		1.34 (1.09–1.65)^**
ICU	0.50 (0.39–0.64)^***	0.66 (0.54–0.80)^***		1.44 (1.15–1.82)^**
Ward/nursing home	Reference	Reference		Reference
Focus of infection
Respiratory	0.72 (0.56–0.92)^*	0.77 (0.62–0.95)^*		0.89 (0.71–1.11)
Abdominal	1.32 (1.04–1.68)^*	1.38 (1.12–1.69)^**		0.44 (0.34–0.56)^***
Urogenital	0.86 (0.59–1.27)	1.20 (0.88–1.63)		0.95 (0.69–1.31)
Bones/soft tissue	1.38 (0.99–1.91)	1.39 (1.05–1.85)^*		0.76 (0.54–1.08)
Other/unknown	Reference	Reference		Reference
Age (per 10 years)	1.11 (1.04–1.18)^***	1.15 (1.09–1.22)^***		0.87 (0.82–0.92)^***
BMI (per 5 points)	0.82 (0.76–0.87)^***	0.92 (0.88–0.97)^**		1.03 (0.99–1.08)
Procalcitonin log10	0.96 (0.85–1.08)	1.01 (0.92–1.12)		1.43 (1.28–1.60)^***
Mean temperature (per 10 °C)	0.83 (0.74–0.93)^**	1.01 (0.91–1.11)		1.12 (0.99–1.25)

Multinomial hierarchical logistic regression model with random intercepts for study centers for the prediction of body temperature category based on 5166 cases with all necessary data available
Leucopenia, leucocyte count and sex were not significantly associated and omitted from the final model. p values were < 0.001 for all predictors included in the model. ^*Denotes predictors significantly associated (^*p < 0.05, ^**p < 0.01, ^***p < 0.001) with the body temperature category

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