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Fig. 1 | Critical Care

Fig. 1

From: Ceftolozane/tazobactam probability of target attainment and outcomes in participants with augmented renal clearance from the randomized phase 3 ASPECT-NP trial

Fig. 1

PTA for ceftolozane and tazobactam in simulated patients with vHABP/VABP by renal function. Panels A and B represent PTA for ceftolozane at a target of 50% fT > MIC. Panels C and D represent PTA for tazobactam at a target of 35% fT > CT. Left panels represent PTA in plasma and right panels represent PTA in ELF. Solid horizontal line on plots represents 90% PTA; vertical line in panels A and B represents an MIC of 4 μg/mL; vertical line in panels C and D represents a CT of 1 μg/mL. CrCl creatinine clearance, CT threshold concentration, ELF epithelial lining fluid, fT > CT time period that the free drug concentration remained above the threshold concentration, fT > MIC time period that the free drug concentration exceeded the MIC value, MIC minimum inhibitory concentration, PD pharmacodynamic, PK pharmacokinetic, PTA probability of target attainment, vHABP/VABP ventilated hospital-acquired bacterial pneumonia/ventilator-associated bacterial pneumonia

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Critical Care

ISSN: 1364-8535