Table 1 Patient characteristics with maintained (TOx < 0) or impaired (TOx > 0) cerebrovascular reactivity (CVR)
Characteristic | Data available | All n = 108 | Maintained CVR n = 32 | Impaired CVR n = 76 | p-value |
|---|---|---|---|---|---|
Gender, n% (male) | 108 | 90 (83.3%) | 24 (75.0%) | 66 (73.3%) | 0.133 |
Age, years | 108 | 61.0 (53.0–70.0) | 55.0 (44.5–69.0) | 61.0 (53.0–66.3) | 0.057 |
BMI | 106 | 26.3 (23.4–29.4) | 26.3 (24.2–28.6) | 26.1 (23.3–29.4) | 0.866 |
Neurologic function before cardiac arrest | 108 | 0.950 | |||
Normal, CPC1, n (%) | 101 (93.5%) | 30 (93.8%) | 71 (93.4%) | ||
Some disability, CPC2, n (%) | 7 (6.5%) | 2 (6.3%) | 5 (6.6%) | ||
Cardiac arrest characteristics and resuscitation factors | |||||
Bystander CPR or compressions only, n (%) | 108 | 88 (81.5%) | 25 (78.1%) | 63 (82.9%) | 0.564 |
Initial rhythm | 108 | 0.359 | |||
VF, n (%) | 106 (98.1%) | 32 (100.0%) | 74 (97.4%) | ||
VT, n (%) | 2 (1.9%) | 0 (0%) | 2 (2.6%) | ||
Time to BLS, min | 106 | 7.0 (6.0–9.0) | 7.0 (6.0–10.0) | 8.0 (6.0–9.3) | 0.813 |
Time to ALS, min | 106 | 10.0 (8.0–12.0) | 9.0 (7.5–12.0) | 10.0 (8.0–12.0) | 0.643 |
Time to ROSC, min | 106 | 21.0 (16.0–25.0) | 17.7 (15.5–25.0) | 18.8 (14.1–24.5) | 0.197 |
GCS after ROSC | 99 | 3.0 (3.0–3.0) | 3.0 (3.0–4.5) | 3.0 (3.0–3.3) | 0.093 |
Medical history | |||||
IHD (NYHA class IV), n (%) | 107 | 2 (1.9%) | 0 (0%) | 2 (2.7%) | 0.353 |
HTA, n (%) | 108 | 54 (50.0%) | 10 (31.3%) | 44 (57.9%) | 0.012 |
Smoker, n (%) | 95 | 32 (33.7%) | 10 (37.0%) | 22 (32.4%) | 0.665 |
Treatment | |||||
PCI before ICU admission | 108 | 53 (49.1%) | 14 (43.8%) | 39 (51.3%) | 0.477 |
Severity of illness score | |||||
Apache II | 108 | 27.0 (24.0–30.0) | 27.0 (24.0–29.0) | 27.0 (24.0–31.3) | 0.119 |
Targeted temperature management | 108 | 0.140 | |||
33 °C, n (%) | 77 (71.3%) | 26 (34.0%) | 51 (66.0%) | ||
36 °C, n (%) | 31 (28.7%) | 6 (20.0%) | 25 (80.0%) | ||
EEG – beginning POOR | 107 | 81 (75.7%) | 24 (77.4%) | 57 (75.0%) | 0.794 |
EEG – end POOR | 107 | 36 (33.6%) | 9 (29.0%) | 27 (35.5%) | 0.523 |
Brain oedema, NO | 108 | 108 (100%) | 32 (100%) | 76 (100%) | |
Duration of mechanical ventilation, hours | 80 | 70.5 (49.5–95.2) | 70.5 (49.1–90.5) | 63.1 (49.2–95.1) | 0.637 |
Length of stay in ICU, hours | 104 | 103.0 (76.6–145.9) | 107.0 (78.5–132.0) | 92.30 (75.0–141.0) | 0.575 |
Mortality 30 d | 108 | 33 (30.6%) | 8 (25.0%) | 25 (32.9%) | 0.418 |
CPC 6 months, poor | 108 | 35 (32.4%) | 9 (28.1%) | 26 (34.2%) | 0.539 |