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Table 1 Patient characteristics with maintained (TOx < 0) or impaired (TOx > 0) cerebrovascular reactivity (CVR)

From: Association of deranged cerebrovascular reactivity with brain injury following cardiac arrest: a post-hoc analysis of the COMACARE trial

Characteristic Data available All
n = 108
Maintained CVR
n = 32
Impaired CVR
n = 76
p-value
Gender, n% (male) 108 90 (83.3%) 24 (75.0%) 66 (73.3%) 0.133
Age, years 108 61.0 (53.0–70.0) 55.0 (44.5–69.0) 61.0 (53.0–66.3) 0.057
BMI 106 26.3 (23.4–29.4) 26.3 (24.2–28.6) 26.1 (23.3–29.4) 0.866
Neurologic function before cardiac arrest 108     0.950
 Normal, CPC1, n (%)   101 (93.5%) 30 (93.8%) 71 (93.4%)  
 Some disability, CPC2, n (%)   7 (6.5%) 2 (6.3%) 5 (6.6%)  
Cardiac arrest characteristics and resuscitation factors      
 Bystander CPR or compressions only, n (%) 108 88 (81.5%) 25 (78.1%) 63 (82.9%) 0.564
 Initial rhythm 108     0.359
  VF, n (%)   106 (98.1%) 32 (100.0%) 74 (97.4%)  
  VT, n (%)   2 (1.9%) 0 (0%) 2 (2.6%)  
 Time to BLS, min 106 7.0 (6.0–9.0) 7.0 (6.0–10.0) 8.0 (6.0–9.3) 0.813
 Time to ALS, min 106 10.0 (8.0–12.0) 9.0 (7.5–12.0) 10.0 (8.0–12.0) 0.643
 Time to ROSC, min 106 21.0 (16.0–25.0) 17.7 (15.5–25.0) 18.8 (14.1–24.5) 0.197
 GCS after ROSC 99 3.0 (3.0–3.0) 3.0 (3.0–4.5) 3.0 (3.0–3.3) 0.093
Medical history      
 IHD (NYHA class IV), n (%) 107 2 (1.9%) 0 (0%) 2 (2.7%) 0.353
 HTA, n (%) 108 54 (50.0%) 10 (31.3%) 44 (57.9%) 0.012
 Smoker, n (%) 95 32 (33.7%) 10 (37.0%) 22 (32.4%) 0.665
Treatment      
 PCI before ICU admission 108 53 (49.1%) 14 (43.8%) 39 (51.3%) 0.477
Severity of illness score      
 Apache II 108 27.0 (24.0–30.0) 27.0 (24.0–29.0) 27.0 (24.0–31.3) 0.119
Targeted temperature management 108     0.140
 33 °C, n (%)   77 (71.3%) 26 (34.0%) 51 (66.0%)  
 36 °C, n (%)   31 (28.7%) 6 (20.0%) 25 (80.0%)  
EEG – beginning POOR 107 81 (75.7%) 24 (77.4%) 57 (75.0%) 0.794
EEG – end POOR 107 36 (33.6%) 9 (29.0%) 27 (35.5%) 0.523
Brain oedema, NO 108 108 (100%) 32 (100%) 76 (100%)  
Duration of mechanical ventilation, hours 80 70.5 (49.5–95.2) 70.5 (49.1–90.5) 63.1 (49.2–95.1) 0.637
Length of stay in ICU, hours 104 103.0 (76.6–145.9) 107.0 (78.5–132.0) 92.30 (75.0–141.0) 0.575
Mortality 30 d 108 33 (30.6%) 8 (25.0%) 25 (32.9%) 0.418
CPC 6 months, poor 108 35 (32.4%) 9 (28.1%) 26 (34.2%) 0.539
  1. Numbers are median (interquartile range) or n (percentage)
  2. CVR cerebrovascular reactivity, BMI body mass index (kg/m2), BLS basic life support, ALS advanced life support, GCS Glasgow coma scale, ROSC return of spontaneous circulation, IHD ischemic heart disease, HTA arterial hypertension, PCI percutaneous coronary intervention